암 환자에게 적용한 심리사회적 중재가 코티졸과 면역기능에 미친 효과: 메타분석 = Effects of Psychosocial Interventions on Cortisol and Immune Parameters in Patients with Cancer: A Meta-analysis

다국어 초록 (Multilingual Abstract)

Purpose: This study was done to evaluate the effects of psychosocial interventions on cortisol and immune response in adult patientswith cancer. Methods: MEDLINE via PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and domestic electronic databases weresearched. Twenty controlled trials (11 randomized and 9 non-randomized trials) met the inclusion criteria with a total of 862 participants.
Methodological quality was assessed using the Cochrane’s Risk of Bias for randomized studies and the Risk of Bias Assessment tool fornon randomized studies. Data were analyzed using the RevMan 5.2.11 program of Cochrane library. Results: Overall, study quality wasmoderate to high. The weighted average effect size across studies was -0.32 (95% CI [-0.56, -0.07], p=.010, I2=45%) for cortisol concentration,-0.62 (95%CI [-0.96,-0.29], p<.001, I2=0%) for T lymphocyte (CD3) and -0.45 (95%CI [-0.74, -0.16], p=.003, I2=0%) for Thlymphocyte (CD4) numbers. Psychosocial interventions were not effective for Tc lymphocyte (CD4), NK cell, monocyte, and cytokine response.
Conclusion: Although these results provide only small evidence of successful immune modulation, they support the conclusionthat psychosocial interventions can assist cancer patients in reducing emotional distress and improving immune response.

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