지방간의 병리학적 소견과 초음파검사의 연관성에 관한 연구 = Correlations Between Histology and Sonographic Findings of Fatty Change in Liver

다국어 초록 (Multilingual Abstract)

BACKGROUND Fatty liver is a common disease characterized by diffuse accumulation of neutral fat(triglycerides) more than 5 percent in liver. Ultrasonography has used to be a diagnostic tool for fatty liver, because of cost-effective and non*invasive study. But the sensitivity and specificity of ultrasonography for diagnosis of fatty liver are variable. Thus, we conducted a retrospective study to investigate correlation between histology and sonographic findings of fatty change in liver.




METHODS We collected data from 47 patients who were diagnosed as fatty liver by liver biopsy and ultrasonography from January, 1994 to December, 1997. We compared a sonographic finding with the histologic grade of fatty liver and analysed the data retrospectively by SAS program.




RESULTS Major cause of fatty liver is alcohol. The mean consumption of alcohol during 1 day is 64,1 gram，and the mean duration of alcohol drinking is 16.5 years, Degree of fatty infiltration in ultrasonography was significantly correlated with degree of fatty accumulation of Iiver(p=0.001), But， though it was diagnosed as normal by ultrasonography, 19.1% of total patients was fatty liver by needle biopsy,

CONCLUSION We think that liver biopsy is needed for further management and follow-up, if liver function test is abnormal，though the finding of ultrasonography is normal