身痛逐瘀湯 및 身痛逐瘀湯加味方의 鎭痛 ·消炎 ·解熱 作用에 관한 硏究 = Experimental Studies of the Sintonchugeotang and Sintongchugeotanggamibang on the Carrageenin-Pretreated Rats

다국어 초록 (Multilingual Abstract)

These experiments were undertaken to investigate the effects of Sintongc-hugeotang(身痛逐瘀湯) and Sintongchugeotanggamibang(身痛逐瘀湯加味方) on the artificial arthritis resulted from Carrageenin. Sprague-Dawley rats body weight 200±10g were used and items which determined in the experiment were articular temperature, volume of the edema, amount of analgesic effect, the number of serum leucocyte of the rats.
The results were summarized as follows:
1. It was recognized that Sintonchugeotang has an effectively decrease on articular temperature, but Sintongchugeotanggamibang had not an effectively decrease on articular temperature.
2. It was recognized that Sintongchugeotang has an anti-inflammatory effect in paw edema induced by Carrageenin, but there was no remarkable altermations in paw edema after administration of Sintongchugeotanggamibang.
3. It was recognized that Sintongchugeotang and Sintongchugeotanggamibang has an effectively analgesic function on the artificial arthritis resulted from Carrageenin.
4. Leucocyte counts in the serum decreased significantly after administration of Sintongchugeotang and Sintongchugeotanggamibang.
According to the above result, it can be concluded Sintongchugeotang and Sintongchugeotanggamibang showed the treatment effect on the arthritis resulted from Carrageenin in rats, and it is suggested that the more interest and study in the security for the clinical use were needed.