Flexible, Transparent, High-performance Multifunctional Electro-optical Bio-interfaces using Ultrathin Gold Films = 초박막 금 박막 기반의 유연하고 투명한 고성능 다기능 전기-광학 생체 인터페이스

목차 (Table of Contents)

• Ⅰ. Introduction 1
• 1.1 Multifunctionality and History of Electro-optical Neural Interfaces 1
• 1.2 Various Modulations with Electro-optical Neural Interfaces 2
• 1.3 The Importance of Transparency in Electro-optical Neural Interfaces 4
• 1.4 Transparent Electro-optical Neural Interfaces: From Materials 5
• 1.5 Transparent Electro-optical Neural Interfaces: From Structures 6
• 1.6 Ultrathin Metal Films as Materials for Electro-optical Neural Interfaces 7
• 1.7 Feasibility of Inkjet Printing Technology for Fabricating Neural Interfaces 9
• 1.8 Dissertation Organization 10
• Ⅱ. Flexible, Transparent, Polymer Seed Layer-based Ultrathin Gold Array 12
• 2.1 Introduction 12
• 2.2 Experimental Section 14
• 2.2.1 Fabrication Process of µECoG Array 14
• 2.2.2 Materials and Methods 15
• 2.3 Results and Discussion 17
• 2.3.1 Material, Electrical, Optical Properties of Polymer Seed Layer-based Ultrathin Gold Film 17
• 2.3.2 Electro-chemical, Optical Properties of µECoG Array 19
• 2.4 Summary 25
• Ⅲ. MXene Interfaced 256-channel Ultrathin Gold Array for Enhancing Electrical Stimulation Properties 27
• 3.1 Introduction 27
• 3.2 Experimental Section 27
• 3.2.1 Fabrication Process of MXene Interfaced µECoG Array 27
• 3.2.2 Materials and Methods 28
• 3.3 Results and Discussion 30
• 3.3.1 Material, Electrical, Optical Properties of MXene Interfaced µECoG Array 30
• 3.3.2 Electro-chemical Properties of MXene Interfaced µECoG Array 31
• 3.3.3 Electrical Stimulation Properties of MXene Interfaced µECoG Array 34
• 3.4 Summary 36
• IV. Electro-optical Neural Recording and Stimulation 37
• 4.1 Introduction 37
• 4.2 Experimental Section 38
• 4.2.1 Materials and Methods 38
• 4.3 Results and Discussion 40
• 4.3.1 In vivo Epicortical Recording with µECoG Array 40
• 4.3.2 Seizure-induced In vivo Epicortical Recording with µECoG Array 44
• 4.3.3 Characterization of Light-induced Artifacts in Electro-optical Neural Interfaces 45
• 4.3.4 In Vivo µECoG Neural Recording and 2D Mapping during Optogenetic Modulation 47
• 4.3.5 Bioimaging Demonstration of Printed µECoG Array 50
• 4.4 Summary 51
• V. Summary, Limitations, and Future Directions 52
• 5.1 Summary 52
• 5.2 Limitations and Future directions 53
• VI. Appendix: Simultaneous Detection of Cellular Temperature Changes and Electrophysiology with Multifunctional Biochip 55
• 6.1 Introduction 55
• 6.2 Experimental Section 56
• 6.2.1 Fabrication Process of tRTD-MEA Biochip 56
• 6.2.2 Materials and Methods 58
• 6.3 Results and Discussion 60
• 6.3.1 Concepts and Device Structures of Transparent RTD-MEA 60
• 6.3.2 Characterization of Transparent Temperature Sensor (tRTD) and Direct Sensing of Photothermal-Induced Heat 65
• 6.3.3 Characterization of Transparent Microelectrode Array 71
• 6.4 Summary 76
• VII. References 78
• VIII. Acknowledgements 90
• Abstract in Korean 92