H2O2에 의한 저분자화 키토산의 제조와 시간경과에 따른 분자량 저하 = Transactions : Depolymerization of Chitosan Using H2O2 and Decrease in Molecular Weight upon Storage Time

다국어 초록 (Multilingual Abstract)

Chitosan was depolymerized by oxidizing agent, hydrogen peroxide (H202) and general properties of resulting low molecular weight chitosan(LMWC) were studied. Effect of amount of H₂O₂, ratio of H₂O₂fchitosan, and reaction temwere investigated in preparing LMWC. In addition, the reduction of molecular weight of prepared LMWC were measured after a certain time passage.Pre-swelling treatment of starting chitosan affected uniform and mild reaction of depolymerization and increased the solubility of resulting LMWC. Prepared LMWC (Mw 100,000) showed a decrease in Mw by 25-35%. Prepared LMWC(Mw 60,000-70,000) showed a decrease in Mw by 10-15% after 7 months. Therefore, this depolymerizing process can be concluded desirable in terms of stability In addition, yellowing of pre-swelling treated chitosan upon time passage was insignificant compared with that of untreated chitosan. Therefore, pre-swelling treatment of chitosan before depolymerization would be beneficial in terms of stability of physical state.