비타민 D 결핍과 저에너지 척추골절의 연관성 = The Association of Low-energy Spine Fractures and Vitamin D Inadequacy: A Case-control Study

다국어 초록 (Multilingual Abstract)

Study Design: Retrospective study.
Objectives: To compare serum vitamin D levels in elderly patients with or without osteoporotic spinal compression fractures (OSCFs) and to identify relationships between the serum vitamin D level and other variables, such as age, bone mineral density (BMD), and bone turnover markers (osteocalcin and C-telopeptide).
Summary of Literature Review: Vitamin D plays a key role in calcium metabolism in the bone tissue. Vitamin D deficiency can lead to decreased BMD and an increased risk of falls and of osteoporotic fractures.
Materials and Methods: We retrospectively reviewed the medical records of 95 elderly patients (≥60 years) with OSCFs (fracture group) and 118 subjects who had been diagnosed with osteoporosis without OSCFs (control group). Serum vitamin D levels were contrasted between the two groups taking into account other factors such as patient age, sex, and seasonal variations. For all the patients, we also evaluated the correlation between the vitamin D level and the patient age, BMD, and bone turnover markers.
Results: The mean of the serum 25(OH) vitamin D3 levels was significantly lower in the fracture group than in the control group. There were significant differences in the 25(OH) vitamin D3 levels in autumn. In all patients, the mean serum 25(OH) vitamin D3 levels were the highest in autumn and the lowest in spring. Furthermore, the mean serum 25(OH) vitamin D3 levels were significantly correlated with patient age and BMD.
Conclusions: A low serum vitamin D level might be a risk factor of OSCFs in elderly patients.

국문 초록 (Abstract)

연구계획: 후향적 연구.
목적: 노인에서의 혈중 비타민 D의 농도와 골다공증성 척추 골절의 관계를 규명하고, 혈중 비타민 D의 농도와 다른 요인들과의 관계를 밝히고자 한다.
선행 연구문헌의 요약: 비타민 D는 골 조직에서의 칼슘 대사에 있어서 아주 중요한 역할을 담당하고 있으며 비타민 D가 부족할 경우 BMD의 감소 및 낙상, 골다공증성 골절의 위험이 증가한다.
대상 및 방법: 저자들은 60세 이상의 환자 중 의료 기록을 통하여 골다공증성 골절이 있는 95명의 환자 및 골절이 없는 골다공증 환자 118명을 분석하였다. 비타민 D와 골다공증성 골절의 관계뿐만 아니라 다양한 요인들과의 상관관계 및 회귀분석을 시행하였다.
결과: 혈중 비타민 D의 농도의 평균은 골다공증성 골절이 있는 그룹에서 골절이 없는 그룹에 비하여 낮았으며 상관 관계가 있는 것으로 나타났으며, 혈중 비타민 D의 농도의 평균은 가을에 가장 높고, 봄에 가장 낮은 것으로 나타났다. 또한 환자의 나이와 BMD와도 상관관계가 있음을 보여주었다.
결론: 노인에서 혈중 비타민 D가 낮은 경우는 골다공증성 골절의 위험인자가 될 수 있다.

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