血府逐 瘀湯이 血栓症과 皮下血腫에 미치는 影響 = Effect of Hyeolbuchugeotang on the Intravascular Coagulation and Subcutaneous Hematoma in Rats

다국어 초록 (Multilingual Abstract)

This study was performed to determine the effects of Hyeolbuchugeotang, which has already been proven to be effective in the treatment of congested blood in the field of Oriental medicine, on intravascular coagulation and sub-cutaneous hematoma .
To do so , an intravascular coagulation was induced in situ by injecting endotoxin in the caudal vein of rats. These rats were then treated with solid extract of Hyeolbuchugeotang(SEH) which was administered orally, Then the numbers of platelets, concentration of fibrinogen and FDP(fibrin-fibrinogen degradation products) were measured . Subcutaneous hematoma was produced by the induction of autologous whole blood to produce clotting in situ in rats. SEH was orally administered to the above rats. The lesions were then dissected and observed.
The following results were obtained :
1. The numbers of platelets increased after the administration of SEH and a double dosage of SEH had more significant effects than a single dosage.
2. Related to the concentration of fibrinogen, SEH-treated groups revealed significant increases .
3. As to the effect on the prothrombin time, SEH-treated groups showed significant reductions.
4. Concerning the degree of concentration of FDP, SEH-treated groups revealed significant decreases.
5. The stabilizing effects of SEH on heat-induced hemolysis appeared at 10 and 20㎎/㎖.
6. 33.3 % of the lesions in the control groups enlarged, while none of the lesions in SEH- treated group enlarged .
7. As to the weight of hematoma, SEH-treated groups revealed significant decreases
8. Histologically, the lesions in SEH-treaded groups formed thinner fibroblastic neomembrance than the control groups. According to the above results, it is concluded that Hyeolbuchugeotang has significant on the fibrinogen and FDP, prothrombin time and heat-induced hemolysis. Hyeolbuchugeotang also inhibited the fibroblastic neormembrane development and subsequent enlargement of subcutaneous hematoma. Therefore it seems to be applicable to diseases related to thrombosis and hematoma.