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    DIAZEPAM (7-chlorl-1,3-dihydro-1-methy1-5-pheny1-2H-1,4-benzodiazepine-2-one)의 경피흡수에 미치는 흡수촉진제의 영향 = Effect of Enhancers on the Percutaneous Absorption of Diazepam (7-chlorl-1,3-dihydro-1-methy1-5-pheny1-2H-1,4-benzodiazepine-2-one)

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    https://www.riss.kr/link?id=A19634445

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    In vivo percutaneous absorption and in vitro diffusion of Diazepam were investigated on microporous membranes (mean pore size ; 0.2μ m) and rabbits dorsal skin under occlusions in the presence of absorption enhancers.
    the absorption of Diazepam percutaneous preparation was increased by adding 2-pyrrolidinone resulting in an approximate 2, 3 fold in Cmax and AUC. The plasma Diazepam Diazepam concentrations after a topical application for 48 hours (3×3㎝ Area, LG of 4％ Diazepam) maintained over the therapeutically effective concentration during 28.55 hours.
    The absolute bioavailability of Diazepam percutaneous preparation with absorption enhancer was 31.67％, which was significantly higher than that(10.29％) of without enhancers.
    In vitro absorption behavior of Diazepam in a Frantz type diffusion cell resembled the result of the in vivo absorption closely
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    In vivo percutaneous absorption and in vitro diffusion of Diazepam were investigated on microporous membranes (mean pore size ; 0.2μ m) and rabbits dorsal skin under occlusions in the presence of absorption enhancers. the absorption of Diazepam perc...

    In vivo percutaneous absorption and in vitro diffusion of Diazepam were investigated on microporous membranes (mean pore size ; 0.2μ m) and rabbits dorsal skin under occlusions in the presence of absorption enhancers.
    the absorption of Diazepam percutaneous preparation was increased by adding 2-pyrrolidinone resulting in an approximate 2, 3 fold in Cmax and AUC. The plasma Diazepam Diazepam concentrations after a topical application for 48 hours (3×3㎝ Area, LG of 4％ Diazepam) maintained over the therapeutically effective concentration during 28.55 hours.
    The absolute bioavailability of Diazepam percutaneous preparation with absorption enhancer was 31.67％, which was significantly higher than that(10.29％) of without enhancers.
    In vitro absorption behavior of Diazepam in a Frantz type diffusion cell resembled the result of the in vivo absorption closely

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