The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be em...
The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be emodin. The minimal inhibitory concentration (MIC) of emodin was 100㎍/㎖ against S. mutans OMZ 176.
The bioactive component emodin weakly inhibited β-lactamase activity with the inhibition ratio of 1.7, 4.3 and 7.6% at the concentration of 50, 100, and 200 μM, respectively. Emodin exhibited slight phototoxicity when analysed by the photohemolysis method.