Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction

다국어 초록 (Multilingual Abstract)

This study was to determine the correlation between endothelial function and neuro-endocrineimmune(NEI) network through observing the changes of NEI network under the different endothelialdysfunction models. Three endothelial dysfunction models were established in male Wistar rats afterexposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that therewas endothelial dysfunction in all three models with varying degrees. However, the expression of NEInetwork was totally different. Interestingly, treatment with simvastatin was able to improve vascularendothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group.
The results indicated that NEI network may have a strong association with endothelial function, andthis relationship can be used to distinguish different risk factors and evaluate drug effects.

참고문헌 (Reference)

1 Muller O, "von Willebrand factor inhibition improves endothelial function in patients with stable angina" 6 : 364-370, 2013

2 Picchi A, "Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome" 99 : 69-77, 2006

3 Ross R, "The pathogenesis of atherosclerosis: a perspective for the 1990s" 362 : 801-809, 1993

4 Nicholson JK, "The metabolome-wide association study: a new look at human disease risk factors" 7 : 3637-3638, 2008

5 Razvi S, "The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial" 92 : 1715-1723, 2007

6 이상기, "Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells" 대한약리학회 16 (16): 199-204, 2012

7 Puranik R, "Smoking and endothelial function" 45 : 443-458, 2003

8 Wagner J, "Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection" 38 : 1241-1254, 1982

9 Chapin JK, "Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations" 94 : 121-140, 1999

10 Ansar S, "Postprandial hyperlipidemia, endothelial dysfunction and cardiovascular risk: focus on incretins" 10 : 61-, 2011

11 del Rey A, "Neuroimmunomodulation in health and disease" 1262 : 7-8, 2012

12 Besedovsky H, "Network of immune-neuroendocrine interactions" 27 : 1-12, 1977

13 Chen M, "Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model" 4 : 2391-2396, 2005

14 Besedovsky HO, "Introduction: immune-neuroendocrine network" 29 : 1-14, 2002

15 Freimark D, "Impact of short-term intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure" 148 : 878-882, 2004

16 Berger MM, "Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema" 172 : 763-767, 2005

17 Durand P, "Hyperhomocysteinemia induced by folic acid deficiency and methionine load--applications of a modified HPLC method" 252 : 83-93, 1996

18 Chen Y, "High levels of soluble intercellular adhesion molecule-1, insulin resistance and saturated fatty acids are associated with endothelial dysfunction in healthy adolescents" 211 : 638-642, 2010

19 조영석, "Ginsenoside Rg2 Inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cell" 대한약리학회 17 (17): 133-137, 2013

20 Shimbo D, "Endothelial dysfunction and the risk of hypertension: the multi-ethnic study of atherosclerosis" 55 : 1210-1216, 2010

21 Cabral MD, "Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism" 66 : 1321-1328, 2011

22 Koh KK, "Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability" 47 : 648-657, 2000

23 Wilbert-Lampen U, "Effects of corticotropin-releasing hormone (CRH)on endothelin-1 and NO release, mediated by CRH receptor subtype R2: a potential link between stress and endothelial dysfunction?" 61 : 453-460, 2006

24 Szabó C, "Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation" 10 : 28-35, 2004