Effect of Casein Hydrolysate, Prepared with Protease Derived from Aspergillus oryzae, on Subjects with High-Normal Blood Pressure or Mild Hypertension

다국어 초록 (Multilingual Abstract)

Casein hydrolysate, prepared with Aspergillus oryzaeprotease, contains angiotensin I-converting enzyme in-hibitory peptides, such as Val-Pro-Pro and Ile-Pro-Pro. We conducted a randomized, double-blind, placebo-controlled studyto evaluate the effect of casein hydrolysate on the blood pressure of 144 subjects with high-normal blood pressure (n . 104)and mild hypertension (n . 40). Subjects were randomly assigned to two groups for a 12-week intake period. In the test group,both systolic (SBP) and diastolic (DBP) blood pressure decreased significantly compared with the placebo group: SBP/DBPsignificantly decreased from 138.2. 6.5/84.4. 5.3 mm Hg at week 0 to 132.3. 7.3 (P. .001)/81.2. 4.8 mm Hg (P..001) at week 12. In the stratified analysis, the test product showed an antihypertensive effect in both the subject group withhigh-normal blood pressure and that with mild hypertension. No side effect was observed in any subjects in this study. Theseresults demonstrate that the casein hydrolysate, prepared with A. oryzaeprotease, produced a significant reduction in bloodpressure in a population of subjects with high-normal blood pressure or mild hypertension without an adverse event.

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