비만여성에 수영운동이 체중과 체지방량, leptin, ghrelin, superoxide dismutase 및 malondialdehyde에 미치는 영향

다국어 초록 (Multilingual Abstract)

The purpose of this study was carried to investigate the effect s of long term swimming exercise on blood leptin, ghrelin, superoxide dismutase(SOD) and lipid peroxidation in obese women. The subjects randomly assigned into two groups: obese group (control group, n=10) and obese and swimming exercise group (exercise group, n=10). Swimming training group was trained 4 days per weeks, for 12 weeks, swimming for 2 hour. The results of this study as follows. Weight and percent body fat were significantly decrease in swimming exercise group. Leptin was significantly decreasd in swimming exercise group, while ghrelin was significantly increased in the swimming exercise group compared to non-exercise obese group. SOD was significantly increased in swimming exercise group, while malondialdehyde(MDA) was significantly decreased in the swimming exercise group compared to non-exercise obese group. The p resent results show that swimming exercise improved lipid peroxidation defence capacities against free radicals generation by increasing by SOD activity, and modulating obesity related genes as leptin, ghrelin, likely as a result of an adaptative increase in activities of antioxidant system in obese women.

참고문헌 (Reference)

1 김성수, "장기간의 지구성 훈련이 쥐의 혈중 항산화 효소 , GSH 및 지질 과산화에 미치는 영향" 7 : 185-194, 1998

2 유형준, "당뇨병 환자의 적혈구막 지질과산화에 미치는 연령의 영향" 8 : 281-286, 1993

3 김기훈, "단기간 절식 및 반복적 절식과 재식이에 따른 식욕조절호르몬과 아디포넥틴 활성의 변화" 한국영양학회 45 (45): 5-11, 2012

4 Nielsen, F., "plasma malondialdehyde as biomarker for oxidative stress:reference interval and effects of life-style factors" 43 : 1209-1214, 1997

5 Foster, C. M., "ghrelin concentrations reflect body mass index rather than feeding status in obese girls" 62 : 731-734, 2007

6 Hansen, T. K., "Weight loss increases circulating levels of ghrelin in human obesity" 56 : 203-206, 2002

7 Packer, L., "Vitamin E, physical exercise and tissue damage in animals" 62 : 105-109, 1984

8 Chow, C. K., "Vitamin E and oxidative stress" 11 : 215-232, 1991

9 Hadjigogos, K., "The role of free radicals in the pathogenesis of rheumatoid arthritis" 45 : 7-13, 2003

10 Evans, W. J., "The metabolic effects of exercise induced muscle damages, In Exercise & Sport Science Review" Williams & Wilkins 99-125, 1991

11 Badman, M. K., "The gut and energy balance : visceral allies in the obesity wars" 307 : 1909-1914, 2005

12 Quintanilha, A. T., "The effect of physical exercise and /or vitamin E on tissue oxidative metabolism" 12 : 403-404, 1984

13 Kowalska, I., "The effect of fasting and physical exercise on plasma leptin concentrations in high-fat fed rats" 50 : 309-320, 1999

14 Reznick, A. Z., "The effect of exercise on enzymes activities in casrdiac muscle of mice of various ages" 28 : 347-352, 1982

15 Parati, G., "Sleep apnea: epidermiology, pathophysiology, and relation to cardiovascular risk" 293 : 1671-1683, 2007

16 Tungtrongchitr, R., "Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese" 86 : 543-541, 2003

17 Jurimae, J., "Regular physical activity influence plasma ghrelin concentration in adolescent girls" 39 : 1736-1741, 2007

18 Halliwell, B., "Protection against oxidants in biological systems: the superoxide theory of oxygen toxicity. In Free Radicals in Biology and Medicine, 2nd Ed" Clarendon Press 1989

19 Zhang, Y., "Positional cloning of the mouse obese gene and its human homologue" 372 : 425-432, 1994

20 Ustundag, B., "Oxidative status and serum leptin levels in obese prepubertal children" 25 : 479-483, 2007

21 Higdon, J. V., "Obesity and oxidative stress: a direct link to CVD?" 23 : 365-367, 2003

22 Fotino, M., "Micromethod for rapid separation of lymphocytes from peripheral blood" 1 : 1131-1133, 1971

23 Bray, G. A., "Medical consequences of obesity" 89 : 2583-2599, 2004

24 Caro, J. F., "Leptin; The tale of an obesity gene" 45 : 1455-1462, 1996

25 Maffei, M., "Leptin levels in human and rodent : measurement of plasma leptin and ob RNA in obese and weight-reduced subjects" 1 : 1155-1161, 1995

26 Hirai, N., "Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. American Journal of Physiology" 279 : 1172-1178, 2000

27 Chang, S. P., "Increase of anti-oxidation by exercise in the liver ofobese Zucker rats" 31 : 506-611, 2004

28 Hirashima, O., "Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species" 35 : 1860-1866, 2000

29 Yoshimatsu, H., "Hypothalamic neuronal histamine as a target of leptin in feeding behavior" 48 : 2286-2291, 1999

30 Foster-Schubert, K. E., "Human plasma ghrelin levels increase during a one-year exercise program" 90 : 820-825, 2005

31 Asakawa, A., "Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin" 120 : 337-345, 2001

32 Kojima, M., "Ghrelin is a growth-hormone-releasing acylated peptide from stomach" 402 : 656-660, 1999

33 Davies, K. J., "Free radicals and tissue damage produced by exercise" 107 : 1198-1205, 1982

34 Jenkins, R. R., "Free radical chemistry : relationship to exercise" 5 : 156-170, 1988

35 Matsuki, N., "Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes" 53 : 1001-1007, 1991

36 Sumida, S., "Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation" 21 : 835-838, 1989

37 Ji, L. L, "Exercise and oxidative stress: Role of the cellular antioxidant systems, In Exercise and Sports Science Review" Williams & Wilkins 1995

38 Salminen, A., "Endurance training reduces the susceptibility of mouse skeletal muscle to lipid peroxidation in vitro" 117 : 109-113, 1983

39 Avellini, L., "Effect of exercise training, selenium and vitamin E on some free radical scavengers in horses (Equus caballus)" 123 : 147-154, 1999

40 Tschöp, M., "Circulating ghrelin levels are decreased in human obesity" 50 : 707-709, 2001

41 Leicy, H. J., "Circulating Ghrelin is sensitive to changes in body weight during a diet and exercise program in normal weight young women" 89 : 2659-2664, 2004

42 Duthie, G. G., "Blood antioxidant status and erythrocyte lipid peroxidation following distan ce running" 282 : 78-83, 1990

43 Tiidus, P. M., "Antioxidant and oxidative enzyme adaptations to vitamin E deprivation and training" 26 : 354-359, 1994

44 Leeuwenburgh, C., "Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific" 272 : 363-369, 1997

45 Urakawa, H., "Adachi Y. Oxidative stress is associated with adiposity and insulin resistance in men" 88 : 4673-4676, 2003

46 Schmidt, A., "Acute exercise has no effect on ghrelin plasma concentration" 36 : 174-177, 2004

47 Perusse, L., "Acute and chronic effects of exercise on leptin levels in humans" 83 : 5-10, 1997