목 적: 조기유방암의 치료에 있어 과거에는 유방 전적출술이 주된 치료였으나 현재는 유방보존술이 표준 치료방법 으로 정립되었다. 저자들은 서울대학교병원에서 유방보존수술 및 방사선...
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https://www.riss.kr/link?id=A82297011
2008
-
510
KCI등재,SCOPUS
학술저널
142-148(7쪽)
2
0
상세조회0
다운로드국문 초록 (Abstract)
목 적: 조기유방암의 치료에 있어 과거에는 유방 전적출술이 주된 치료였으나 현재는 유방보존술이 표준 치료방법 으로 정립되었다. 저자들은 서울대학교병원에서 유방보존수술 및 방사선...
목 적: 조기유방암의 치료에 있어 과거에는 유방 전적출술이 주된 치료였으나 현재는 유방보존술이 표준 치료방법
으로 정립되었다. 저자들은 서울대학교병원에서 유방보존수술 및 방사선치료를 받은 환자의 임상적 특성을 조사
하고 치료결과 및 예후인자를 분석하고자 하였다. 대상 및 방법: 1992년 2월부터 2002년 1월까지 침윤성 유방암으로 유방보존수술 및 수술 후 방사선치료를 받은 424명을 대상으로 후향적으로 분석하였다. 대부분의 환자는 사분절제술 및 액와림프절 청소술을 시행 받았다(396명, 93.4%). 302명이 T1이었고 122명은 T2 병기였으며, 림프절 전이는 107명에서 확인되었다. 방사선치료는 전체 유방에 28회에 걸쳐 50.4 Gy를 조사한 후 종양이 있었던 부위에 10 Gy의 추가조사를 실시하였다. 영역림프절 조사는 57명에서 시행되었다. 항암화학요법은 231명에서 시행되었으며, 그 중 170명이 cyclophosphamide, methotrexate 및 5-fluorouracil을 투여 받았다. 중앙추적기간은 64개월이었다. 결 과: 전체 환자의 5년 국소제어율은 95.6%이었다. 추적관찰 중 15명의 환자에서 국소재발이 확인되었다. 5년 생존율은 93.1%이었고, 병기에 따른 5년 생존율은 I기 94.8%, IIA기 95.0%, IIB기 91.1%, IIIA기 75.9%, IIIC기 57.1% 이었다. 5년 무병생존율은 88.7%이었고, 병기별로는 I기 93.1%, IIA기 89.4%, IIB기 82.8%, IIIA기 62.0%, IIIC기 28.6%이었다. 예후인자 분석에서는 N 병기(p=0.0483)가 생존율에, 연령(p=0.0284)과 N 병기(p=0.0001)가 무병생존율에 각각 유의한 영향을 보였다.
결 론: 조기유방암에서 유방보존수술 및 수술 후 방사선치료는 우수한 국소제어율 및 생존율을 기대할 수 있는 치료법임을 확인할 수 있었다.
다국어 초록 (Multilingual Abstract)
Purpose: We analyzed the treatment outcomes and prognostic factors of breast conserving surgery, followed by postoperative radiotherapy. Materials and Methods: A total of 424 breast cancer patients treated with breast conserving surgery and postopera...
Purpose: We analyzed the treatment outcomes and prognostic factors of breast conserving surgery, followed by
postoperative radiotherapy. Materials and Methods: A total of 424 breast cancer patients treated with breast conserving surgery and postoperative radiotherapy between February 1992 and January 2001 were retrospectively analyzed. A quadrantectomy and axillary lymph node dissection was performed in 396 patients. A total of 302 patients had T1 disease, and 122 patients had T2 disease. Lymph node involvement was confirmed in 107 patients. Whole breast irradiation was administered at up to 50.4 Gy in 28 fractions, followed by a 10 Gy boost in 5 fractions to the tumor bed. In addition, 57 patients underwent regional lymph node irradiation. Moreover, chemotherapy was administered in 231 patients. A regimen consisting of cyclophosphamide, methotrexate, and 5-fluorouracil was most frequently used with 170 patients. The median follow-up time was 64 months. Results: The 5-year local control rate was 95.6%. During the follow-up period, local tumor recurrence was observed in 15 patients. The 5-year overall and disease-free survival rates were 93.1% and 88.7%, respectively. The 5-year overall survival rates, by stage, were 94.8% for stage I, 95.0% for stage IIA, 91.1% for stage IIB, 75.9% for stage IIIA, and 57.1% for stage IIIC. As for disease-free survival, the corresponding figures, by stage (in the same order), were 93.1%, 89.4%, 82.8%, 62.0%, and 28.6%, respectively. The advanced N stage (p=0.0483) was found to be a significant prognostic factor in predicting poor overall survival, while the N stage (p=0.0284) and age at diagnosis (p=0.0001) were associated with disease-free survival. Conclusion: This study has shown that breast conserving surgery and postoperative radiotherapy for early breast cancer results was excellent for local control and survival.
참고문헌 (Reference)
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2 Fisher B, "Twenty-year followup of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer" 1233-1241, 2002
3 Veronesi U, "Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer" 1227-1232, 2002
4 Hankey BF, "Trends in breast cancer in younger women in contrast to older women" 16 : 7-14, 1994
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6 Cox JD, "Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)" 31 : 1341-1346, 1995
7 Koh KW, "The results of primary radiotherapy following breast-conserving surgery for early breast cancer" 13 : 163-171, 1995
8 Ahn SH, "The Korean Breast Cancer Society. Chronological changes of clinical characteristics in 31115 new breast cancer patients among Koreans during 1996-2004" 99 : 209-214, 2006
9 Fyles AW, "Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer" 963-970, 2004
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11 Nixon AJ, "Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer" 12 : 888-894, 1994
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14 Lee MZ, "Radiation therapy for operable breast cancer after conservative surgery" 20 : 309-315, 2004
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17 Bartelink H, "Psychological effects of breast conserving therapy in comparison with radical mastectomy" 11 : 381-385, 1985
18 Cianfrocca M, "Prognostic and predictive factors in early-stage breast cancer" 9 : 606-616, 2004
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20 Wolmark N, "Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18" 30 : 96-102, 2001
21 Freedman G, "Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy" 44 : 1005-1015, 1999
22 Park CC, "Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and ystemic therapy on local recurrence" 18 : 1688-1675, 2000
23 Goldhirsch A, "Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005" 16 : 1569-1583, 2005
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Postoperative External Beam Radiotherapy for Retroperitoneal Soft Tissue Sarcoma
초기 자궁내막암의 수술 후 방사선치료의 결과와 예후인자
진행성 비소세포폐암 환자에서 Gemcitabine/Cisplatin을 이용한 동시 화학 방사선 요법
In-vitro와 Ex-vivo MTT Assay를 통한 직장암의 방사선치료 감수성 예측 가능성 검증
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2024 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2021-01-01 | 평가 | 등재학술지 선정 (해외등재 학술지 평가) | ![]() |
2020-12-01 | 평가 | 등재후보로 하락 (해외등재 학술지 평가) | ![]() |
2015-01-01 | 평가 | SCOPUS 등재 (기타) | ![]() |
2013-01-01 | 평가 | 등재후보 1차 FAIL (등재후보1차) | ![]() |
2012-04-01 | 평가 | 등재후보로 하락 (기타) | ![]() |
2012-01-01 | 평가 | 등재후보학술지 유지 (기타) | ![]() |
2011-12-30 | 학회명변경 | 영문명 : The Korean Society For Therapeutic Radiology And Oncology -> The Korean Society for Radiation Oncology | ![]() |
2011-08-22 | 학술지명변경 | 한글명 : 대한방사선종양학회지 -> Radiation oncology journal 외국어명 : The Journal of the Korean Society for Therapeutic Radiology and Oncology -> Radiation oncology journal | ![]() |
2009-01-01 | 평가 | 등재 1차 FAIL (등재유지) | ![]() |
2006-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2005-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2004-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | ![]() |
2002-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.31 | 0.31 | 0.25 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.23 | 0.22 | 0.864 | 0.05 |