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https://www.riss.kr/link?id=A3306186
1989
-
500
KCI등재후보
학술저널
37-44(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Adult T-lymphoblastic lymphoma was first described by Barcos and Lukes in 1974. It is famous for early systemic metastasis and should be treated systematically as soon as possible. We diagnosed 8 adult T-lymphoblasic lymphomas by means of clinical man...
Adult T-lymphoblastic lymphoma was first described by Barcos and Lukes in 1974. It is famous for early systemic metastasis and should be treated systematically as soon as possible. We diagnosed 8 adult T-lymphoblasic lymphomas by means of clinical manifestation, tissue biopsy and their immunophenotyping from May 1986 to September 1988. Seven cases were treated with an aggressive regimen, the modified LSA2-L2 protocol. The results were as follows: 1) The median age in the group was 24 years (range 17 -35). 2) At diagnosis, all patients had mediastinal involvement, and 5 patients had bone marrow involvement. Three patients demonstrated malignant cells in the peripheral blood. 3) Six patients were positive for Tdt stain and 4 patients were CD7 (+). 4) Complete clinical response was attained in all patients with induction therapy including cytoxan, vincristine, and adriamycin. 5) Two complete responders who did not take the prescribed chemotherapeutic medication and CNS prophylaxis have had relapses in the CNS and testis. In summary, adult T-lymphoblastie lymphoma is a very aggressive and systemic disease. Systemic chemotherapy with CNS prophylaxis, such as the modified LSA2-L2 protocol, should be recommended.