高壓 酸素 療法이 複合 租織 移植에 미치는 影響 = EXPERIMENTAL STUDY TO THE EFFECT OF HYPERVARIC OXYGEN ON THE SURVIVAL OF THE COMPOSITE GRAFT

다국어 초록 (Multilingual Abstract)

Even thought the composite graft has many advantage, its clinical use has been limited survival. Early vascularization from the recipient site is essential for the survival of the composite graft.
We grafted 15mm-sized composite tissue on the rabbit ear. And the rabbit was treated with hyperaric oxygen or calcium antagonist.
The survival area, survival rate, gross and histologic change were studied using the biopsy specimen which was taken on 2nd, 5th, 7th, and 14th postoperative day.
The result are as follows;
1. The survival rate of hyperbaric oxygen treated group(89.7%) was significantly higher than that of the control group(65.3%).(p<0.001)
2. The survival rate of the calcium antagonist treated group(67.5%) was not significantly higher than the control group(65.3%).(P>0.1)
3. The color of the graf was monitored. At postoperative 24-48 hours, the color of the graft truned into pink-tined tone, and than changed into purple color at postoperative 4th-5th day.
The color of the graft returned to nomal pinkish hue at 7th-10th postoperative day. We observed the same color change in each groups of survived composite graft.
4. The histologic finding of the hyperbaric oxygen treated group was compaired to those of the control or calcium antagonist treated group. The hyperbaric oxygen treated group showed less degeneration of epithelial cells and chondrocytes as well as less interstitial edema, but it showed increased chondroblasts and chondrocyte layers.
In conclusion, we noticed that the hyperbaric oxygen treatment significantly increases the survival of the composite graft.