아토피피부염 환자에 대한 thymopentin 의 치료효과 = The efficacy of thymopentin in the treatment of atopic dermatitis

다국어 초록 (Multilingual Abstract)

Background: Thymopentin(TP-5) is an immunomodulatory agent which may be a promising new drug in the treatment of patients with severe atopic dermatitis. Objective: The aim of this study was to evaluate the efficacy of thymopentin for treatment of severe atopic dermatitis. Material and Method: Fifteen patients with severe atopic dermatitis received subcutaneous injections of 50mg thymopentin three times per week for 6 weeks. Clinical extent and severity parameters were assessed at baseline, at regular intervals during therapy and 4 weeks posttherapy. Use of antihistamine and topical steroid were permitted. Result: Significant reduction in severity scores and body surface area involvement was ob- served and no significant side effects were noted(p<0.05). Conclusion : Thymopentin may be considered to be an effective adjunctive therapeutic agent in the treatment of severe atopic dermatitis. Further studies will be needed to determine the action mechanism of thymopentin.