알레르기성 비염 및 기관지천식 환자에서의 비점막 항원 유발시험이 비특이적 기관지 과민반응에 미치는 영향

다국어 초록 (Multilingual Abstract)

The relationship between allergic rhinitis and bronchial asthma is controversial. To assess the relationship, we sought to determine the effect of nasal allergen exposure on lower airway reactivity in subjects with allergic rhinitis and asthma. Airway Hyperresponsiveness was evaluated by methacholine bronchial provocation test in basal conditions and 16 hours after specific nasal provocation test with D. pteronyssinus (6 subjects), D. farinae (1 subject), or ragweed (1 subject) allergens. Nasal provocation test was performed by applying paper disks soaked with increasing concentrstions of allergen extrsct solutions to the inferior turbinates of both sides of the nose until a positive response was achieved. Responses to nasal provocation test were evaluated by means of provoked symptoms and nasal flow resistance determined by anterior rhinomanometry. There was no significant difference between basal and post challenge FEV,. All subjects de- veloped severe rhinitis symptoms during the nasal challenge. The degree of nonspecific bronchial hyperresponsiveness determined by PC, methacholine was not significantly changed. This study suggests that bronchial hyper- responsiveness does not change after nasal allergen challenge in subjects with allergic rhintis and bronchial asthma.