Bishpenol A와 인체 위해 연구를 위한 시료 용기에 대한 재고 = Consideration of Biospecimen Containers for Bisphenol A and Human Risk Studies

다국어 초록 (Multilingual Abstract)

Bisphenol A (BPA), an endocrine disruptor, has been emphasized due to its epigenetic characteristics
and potential to increase prostate cancer through second hit mechanism. However, its end points in human
have not been clarified, yet. Thus, the continuous biomonitoring of BPA is an alternative strategy for
prevention of BPA-related cancer. For the proper biomonitoring of BPA, BPA-contamination, which
confounds real exposure of BPA, should be excluded. Most of exposed BPAs to human are metabolized
into conjugated BPA in urine and the conjugated BPA in urine reflects real exposure to BPA. On the
other hand, free BPA reflects contamination of BPA through handling process rather than real exposure.
In the present study, we focused on container-induced BPA and compared free BPA levels in urine
samples, which were stored in the plastic tubes (Conical tube 50050, PP, SPL, Pocheon, Korea), to those
in BPA free-glass tubes (N=16). We quantified BPA with reverse phase-HPLC/FD methods. As a result,
we found that free BPA were not detected in urine samples. Thus, the plastic containers are suitable
for future BPA biomonitoring. (Cancer Prev Res 14, 208-211, 2009)

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