하부 요로의 염증 모델 = Models of Inflammation of the Lower Urinary Tract

국문 초록 (Abstract)

하부요로의 염증은 사람에게 있어서 자주 일어난다. 요로감염을 제외하고는 아직까지 그 원인들이 밝혀져 있지는 않다. 동물모델은 하부요로와 관련된 증상을 조장하는 기전들을 조사하고 연구하며 또한 증상을 억제하는 치료법을 선택하는 연구에 있어 많이 이용되어 왔다. 이번 고찰은 고양이의 간실성 방광염, 신경인성 방광염, 자기면역성 방광염, 화학품 내지 세균성 물질 (lipopolysaccharide; LPS)을주입함으로써 나타나는 방광염을 포함한 다양한 하부요로염증의 동물 모델을 소개할 것이다. 동물 모델을 이용한 실험은 방광 염증을 일으키는 기전을 연구하는 데 있어서 계속 중요한 역할을 할 것이지만 몇몇 동물 모델은 실제 임상적인 질환을 일으키는 원인과 관련이 있는 지는 명확하지 않다. 이러한 주된 이유는 사람에게 있어서 이러한 질환을 일으키는 원인을 충분하게 이해하지 못하는데 있다. 하부 요로 염증의 예방과 치료를 위해서 행해지는 동물 모델 실험을 통해 얻어진 결과를 충분히 이해하기 위해서는 비교하고 번역하는 연구가 필요하다.

참고문헌 (Reference)

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