Cyclocytidine Hydrochloride의 正常흰쥐 血液像에 미치는 影響 = Effect of Cyclocytidine Hydrochloride on Hematological Findings of Normal Rats

국문 초록 (Abstract)

著者는 抗癌劑인 cyclocytidine hydrochloride를 成熟한 흰숫쥐에 腹腔內로 注射한 후 26日間 觀察하고 末梢血液細胞와 骨髓細胞 그리고 造血機能에 미치는 影響을 檢討하였다.
人間에서의 治療量에 該當하는 體重 ㎏當 15㎎을 5日間 投與했을 때는 血色素値, 網赤血球數, 好中球絶對數, 淋巴球絶對數 및 血小板數에 變動이 없었다. 그리고 巨核球數, 有核赤血球數, 骨髓球系絶對數, 淋巴球絶對數 및 赤血球 ^59Fe利用率에 있어서도 對照群에 比하여 意義있게 差가 없었다.
人間의 治療量의 10倍에 該當하는 體重 ㎏當 150㎎를 5日間 投與했을 때는 巨核球數에 있어서만 有意한 差가 있었을뿐 나머지의 檢査種目에 있어서는 意義있는 變動이 없었다.
LD/50量에 該當하는 體重 ㎏當 3,200㎎을 5日間 投與했을 때는 血色素値와 各種 末梢血液細胞의 減少가 있었으며 赤血球 ^59Fe利用率과 各種 骨髓細胞의 激減이 있었다

다국어 초록 (Multilingual Abstract)

The author evaluated the effect of cyclocytidine hydrochloride on peripheral blood cells as well as marrow cells by observing for 26 days in the rats injected with the drug intraperitoneally.
There were no alterations of hemoglobin, reticulocyte count, absolute neutrophil count, absolute lymphocyte count and platelet count in the rats being administered the drug at a dose of 15㎎ per ㎏ corresponding to the therapeutic dose for humans for 5 days. No significant differences were noted in megakaryocyte count, nucleated red cell count, absolute myeloid cell count, absolute lymphocyte count and erythrocyte ^59Fe incorporation rate as compared with those of the control group.
In the rats given the drug at a dose of 150 ㎎ per ㎏ for 5 days, only the megakaryocyte count was found to be significantly decreased. Otherwise no abnormalities were seen.
The rats being given the drug at a dose of 3,200 ㎎ per ㎏ corresponding to LD/50 dose for 5 days showed a markedly decreased hemoglobin, significant reduction of various peripheral components, drastic decrease of erythrocyte ^59Fe incorporation as well as various myeloid cellular elements.