원발성 폐암에서 p53 단백의 발현양상과 예후와의 관계 = Prognostic Significance of p53 Protein Expression of Primary Non - Small Cell Lung Cancer

다국어 초록 (Multilingual Abstract)

Background and the Method: Abnormality of p53 is the most frequent genetic derrangement in the malignant diseases. Some oncogens like myc or erb B2 are known to be a poor prognostic marker in lung cancer, but the relationship of p53 gene mutation and the survival is controversial. Immunohistochemical staing can detect only mutant p53 protein because of markedly prologed half life of mutant p53 protein compared to wild type p53. So, using PAb 1801, we performed the immunohistochemical stain on 38 resected primary non- small cell lung cancer specimens and analyzed the relationship between the expression of p53 protein and the clinical parameters including the survival. Result: p53 protein was detected in 55% of total 38 patients (56% of 25 squamous carcinoma and 70% of 10 adenocarcinoma). p53 protein was postitive in 50% of stage I, 36% of stage II, 78% of stage IIIa, and 50% of stage IIIb. Using the Kaplan-Meier method and SAS statistics program, the survival of p53 protein positive patients was significantly low (p=0.0402) compared to the survival of p53 protein negative patients. The surgical stage also had the significant correlation with the survival. Conclusion: The presence of p53 mutation is a poor prognostic marker.