자궁경부암에서 human papilloma virus 감염과 cyclin D1 발현감소와의 연관성 = Association Between Infection of Human Papillomavirus and Decreased Expression of Cyclin D1 in Cervical Neoplasia

다국어 초록 (Multilingual Abstract)

Cyclin D1, one of G1 cyclin gene subfamily, and human papillomaviruses (HPV) oncoprotein E7 have a homology in binding sites for the retinoblastoma tumor-suppressor protein. In order to evaluate the role of cyclin D1 in human cervical carcinogenesis, the level of its expression was measured and compared to HPV infection. In these studies, 38 normal control cases, 22 carcinoma in situ (CIN) cases, and 16 invasive cervical carcinomas were analyzed by immunocytochemistry and polymerase chain reactions for the detection of expression of cyclin D1 and infection of HPV type 16 and 18, respectively. The cyclin D1 expression was significantly lower in CIN and invasive carcinoma than normal control group regardless of HPV infection (p=0.026). The decreased expression of cyclin D1 in normal control group was not related with HPV infection. However, the levels of expression of cyclin D1 in CIN and invasive carcinoma were correlated with HPV 16and 18 (p=0.026). The expression of cyclin E was not changed in HPV 16 and 18 infected cases. These data provide the evidence that cyclin D1 expression in the lesions of cervical tumor is decreased and it is related with HPU infection.