gallate was previously isolated from Persicaria lapathifolia (Polygonaceae) as an inhibitorof superoxide production. In the present study, quercitrin gallate was found to inhibit interleukin (IL)-6 productionin lipopolysacharide (LPS)-stimulated macro...
gallate was previously isolated from Persicaria lapathifolia (Polygonaceae) as an inhibitorof superoxide production. In the present study, quercitrin gallate was found to inhibit interleukin (IL)-6 productionin lipopolysacharide (LPS)-stimulated macrophages RAW 264.7 with an IC50 value of 63M. Furthermore,quercitrin gallate attenuated LPS-induced synthesis of IL-6 transcript but also inhibited LPS-induced IL-6promoter activity, indicating that the compound could down-regulate IL-6 expression at the transcription level.y role in LPS-inducible IL-6 expression, an effect ofquercitrin gallate on LPS-induced NF-kB activation was further analyzed. Quercitrin gallate exhibited a dose-dependent inhibitory effect on LPS-induced nuclear translocation of NF-kB without affecting inhibitory kB (IkB)degradation, and subsequently inhibited LPS-induced NF-kB transcriptional activity in macrophages RAW 264.7.Taken together, quercitrin gallate down-regulated LPS-induced IL-6 expression by inhibiting NF-kB activation,diseases.KeywordsQuercitrin gallate, IL-6 expression, NF-kB activation, macrophages RAW 264.7