The effects of thyroid hormone disruption on reproduction in zebrafish: a transcriptome analysis

다국어 초록 (Multilingual Abstract)

Thyroid hormone (TH) is well-known regulator of development and it’s metabolism in vertebrates. Several studies reported that TH is related to the gonadal differentiation and the reproductive function on individual level of fish. To explore the reproductive toxic biomarker based on the transcriptomic profile in the larva stage of zebrafish (Danio rerio) exposed to TH (triiodothyronine, T3) and thyroid peroxidase inhibitor (propylthiouracil, PTU), we were analyzed in terms of Differential Expressed Gene (DEG), Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses. When compared to the control, the genes related sex steroid hormone synthesis (i.e., estrogen, androgen) and oocyte maturation were changed in zebrafish exposed to T3 or PTU. Therefore, it is possible that TH is contribute to sexual maturation in female via sex steroid synthesis. In addition, The genes related to oocyte maturation, including sex steroid hormone, may be used as biomarkers for screening reproductive toxicity by chemicals that could cause thyroid hormone disruption.