압출법을 이용한 골대체제용 다공성 인산칼슘 세라믹 개발 = Porous Calcium Phosphate Ceramics Developed by Extrusion Method for Bone Substitutes

다국어 초록 (Multilingual Abstract)

Bone growth into a porous structure can be accelerated by the control of size, shape, volume and interconnectivity of the pores. The 3-dimensional interconnectivity of pore structures is one of important features for bone substitutes and tissue engineering scaffolds. The 3-D interconnected porous calcium phosphate ceramics were prepared using an extrusion method with a syringe in this study. The porosity and compressive strength were carefully examined upon the addition of PMMA (poly-methyl methacrylate) beads and HAp (hydroxyaptite) in a DCPD (dicalcium phosphate dehydrate-CN(calcium nitrate solution) system. Highly porous calcium phosphate ceramics having good compressive strength were obtained using a syringe extrusion method with PMMA beads and HAp. The highly macro- and microporous structured samples were obtained by the addition of PMMA beads and the reaction of DCPD-CN, respectively.
The PMMA beads played the role of a sacrificial template for relatively large pores. The DCPD-calcium reaction generated the micro-pores and channels and connected the large pores which were formed by PMMA beads. The addition of HAp were significantly increased the compressive strength with decreasing porosity. The addition of HAp were also enhanced the phase transformation of calcium phosphates (TCP, CaO, etc) to HAp crystalline. The control of HAp formation can be applied for the control of the biodegradation rate of calcium phosphate. These porous calcium phosphate ceramics with high porosity and compressive strength can be applied for dental and orthopedic areas as a bone substitute materials

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