Insulin 비의존형 당뇨병환자에서 Insulin 과 Gliclazide 병합요법의 효과에 관한 연구 = The Acute Effect of Insulin and Gliclazide Combination Therapy in NIDDM PatientsInsulin 비의존형 당뇨병환자에서 Insulin 과 Gliclazide 병합요법의 효과에 관한 연구

다국어 초록 (Multilingual Abstract)

This study was performed on the acute effect of gliclazide and insulin combination in non insulin dependant diabetic (NIDDM) patients who had been in secondary failure with oral hypoglycemic agents treatment. Thirty minutes after premedication with 80 mg gliclazide or placebo, 11.25 unit of rapid acting recombinant human insulin were infused through the forearm vein for 45 minutes. Blood sugar measurements were made at 10-minute intervals, whereas serum insulin and C-peptide levels were measured at 30-minute intervals. The results were as follows: 1) There was no significant difference in the basal serum insulin concentration before the insulin infusion after placebo and gliclazide administration. Peak serum insulin concentration was attained 30 minutes after insulin infusion. The values were 312±26 μU/ml after placebo administration and 312±19 μU/ml after gliclazide adminisration. 2) Blood sugar levels of both groups fell to 130 mg/dl one hour after insulin infusion and remained at euglycemic state during the study. 3) Although both showed no difference in the basal C-peptide concentration, the serum C-peptide concentration of the gliclazide group was significantly higher than that of the placebo group. These results indicate that gliclazide combined with insulin may increase endogenous insu1in secretory capacity, even in the presence of secondary failure of oral hypoglycemic agents.