Ondansetron과 Dexamethasone의 병합 투여가 복강경하 질식 전자궁 적출술 환자의 수술 후 오심 및 구토, 통증에 미치는 효과 = Effect of Ondansetron combined with Dexamethasone on Postoperative Nausea & Vomiting and Pain of Patients with Laparoscopic Hysterectomy

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-
Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal
hysterectomy under general anesthesia. Methods: Data were collected from April 1 through September 30, 2005 using a
double blind method. Ondansetron 4 mg and dexamethasone 10 mg were administered to the experimental group (25
patients), and ondansetron 4 mg only to the control group (25 patients). The medications were administered through an
intravenous line at the beginning peritoneum suture. PONV by Index of Nausea Vomiting and Retching (INVR), nausea by
Visual Analogue Scale (VAS), and pain (VAS) were assessed at postoperative 1 hr, 3 hr, 6 hr, 24 hr, and 48 hr. Data were
analyzed using repeated measures ANOVA, and Bonferroni methods. Results: The experimental group that received
ondansetron combined with dexamethasone had less PONV (p=.048), and nausea (p=.012) than control group that received
ondansetron alone. However, there was no difference in pain (p=.557) between the patients in the two groups. Conclusion:
We conclude that the administration of ondansetron combined with dexamethasone is more effective than the administration
of ondansetron alone to reduce PONV in patients with laparoscopic hysterectomy.

다국어 초록 (Multilingual Abstract)

Purpose: The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-
Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal
hysterectomy under general anesthesia. Methods: Data were collected from April 1 through September 30, 2005 using a
double blind method. Ondansetron 4 mg and dexamethasone 10 mg were administered to the experimental group (25
patients), and ondansetron 4 mg only to the control group (25 patients). The medications were administered through an
intravenous line at the beginning peritoneum suture. PONV by Index of Nausea Vomiting and Retching (INVR), nausea by
Visual Analogue Scale (VAS), and pain (VAS) were assessed at postoperative 1 hr, 3 hr, 6 hr, 24 hr, and 48 hr. Data were
analyzed using repeated measures ANOVA, and Bonferroni methods. Results: The experimental group that received
ondansetron combined with dexamethasone had less PONV (p=.048), and nausea (p=.012) than control group that received
ondansetron alone. However, there was no difference in pain (p=.557) between the patients in the two groups. Conclusion:
We conclude that the administration of ondansetron combined with dexamethasone is more effective than the administration
of ondansetron alone to reduce PONV in patients with laparoscopic hysterectomy.

참고문헌 (Reference)

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