지질대사 이상과 건강 = Metabolic Abnormality of Lipid and Health

다국어 초록 (Multilingual Abstract)

The human lipoproteins provide an efficient mechanism for transporting water insoluble lipid moities in circulation, Each lipoprotein is composed of non-polar lipid core. Consisting of cholesterol ester aad triglyceride, surrounded by a monolayer membrane of polar lipid in combination with specific proteins (apoproteins). The cholesterol transport from peripheral cells appears to depend on HDL. These lipoproteins can bind to cells without being internalized and remove unesterified cholesterol. Subsequently, the cholesterol can be esterified by LCAT and transferred to lipoproteins that contein apolipoprotein B or E. Either these lipoproteins or HDL can then return cholesterol to the liver. Thus, the liver plays a central role in the regulation plasma cholesterol traffic. It not only secretes cholesterol into both bile and plasma as a component of VLDL but also controls removal of cholesterol via receptors for chylomicron remnant, VLDL remnant, LDL and HDL. Each of these steps appears to be regulated by and subjected to dietary, hormonal and genetic influences. The rationale for treating symptomatic hyperlipidemia is obvious. Prevention of the potentially fatal complication of acute pancreatitis is an absolute indication for treatment of marked hypertriglyceridemia with chylomicronemia. Treatment of asymptomatic disorders is based on the lipid hypothesis that lowering lipid levels will decrease the mobility and mortality from associated atherosclerosis.