피씨비(PCB) 中毒에 미치는 프라센타(Placenta)의 效果 = Effects of Human Placenta Extracts on the PCB Toxicity

다국어 초록 (Multilingual Abstract)

This study was undertaken to investigate the effects of placenta on the toxicity of KC-400 in rabbits.
Rabbits were treated with 800㎎ of KC-400 in 2㎖ olive oil via IP injection intermittently day after day for a week and were successively administered with 2㎖ of the placenta extracts via I. V. injection twice a day after day as well as with the placenta extracts with 50 ㎎ of vitamin C as well.
The results obtained in this experiment were as follows:
1. When the experimental animals were treated with human placenta, there wasn't any alteration of the hematochemical indicators such as RBC, WBC, Hgb, Het, serum Cholesterol, s-GOT, s-GPT, serum Alkaline Phosphatase and Total lipids in serum.
2. According to the experiment of PCB poisoning, while s-C, s-GPT, s-ALP, and s-TL were increased, RBC, WBC, Hgb and Het were decreased during the experimental periods respectively.
3. The placenta extracts normalized the hematochemical indicators of the PCB poisoned animals after one day treated by the placenta extracts.
4. The combined treatment with the placenta extracts and vitamin C was the same effect as the single placenta treatment only; they were not significant in the t-test.
5. The placenta extracts inhibited the serum tyrosinase activity of the rabbits which was induced by PCB in vivo and in vitro respectively.
By the combined treatment with the placenta extracts and vitamin C, the activity of tyrosinase was remarkably inhibited in comparison with the single treatment with the placenta alone.