흰쥐에 對한 Phosphamidon 및 Endosulfan의 亞急性毒性에 關한 硏究 = Studies on the Subacute Toxicity of Phosphamidon and Endosulfan in Rats

다국어 초록 (Multilingual Abstract)

Subacute toxicity tests of phosphamidon and endosulfan were carried out to examine the adverse effects resulting from repeated daily oral administration of low dose levels (1, 2 and 5 mg/kg/day) to rats for 28 days.
The results were summarized as follows:
1. Rats showed clinical signs of salivation hyperactivity, ataxia at 2mg/kg/day dosage of phosphamidon and, in addition, lachrymation, tremor, exophthalmus and diarrhea at the highest level. On the other hand, endosulfan caused only hyperactivity in rats treated with the highest dosage. There was no mortality at any dosage of either pesticide.
2. Rats gained significantly lower body weight, when treated at the 5mg/kg/day dose levels of phosphamidon and endosulfan, in comparison to normal, nontreated rats.
3. Plasma cholinesterase activity was significantly depressed at all levels of phosphamidon during the administration period, but returned to normal within 2 weeks after the last administration. Endosulfan did not change plasma cholinesterase activity at any levels.
4. Leukopenia was detected only in rats treated with phosphamidon at 5mg/kg/day level. No other adverse changes in hematology were observed in rats treated either with phosphamidon at lower levels or with endosulfan at any levels.
5. Cloudy swelling of liver was the only histological change in rats treated with phosphamidon or endosulfan at the highest level. No other histopathological change in rats treated with phosphamidon or endosulfan at the highest level. No other histopathological symptoms were found in spleen, heart, kidney, and bone marrow of rats treated.
6. It may be concluded from the results above that the "no effect level" is 1 mg/kg/day and 2 mg/kg/day for phosphamidon and endosulfan, respectively.