한국인 중증 전자간증 산모에서 Thermolabile Methylenetetrahydrofolate Reductase 유전자의 다양성에 관한 연구 = Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Objective : This study was performed to evaluate C to T substitution at nucleotide 677 of meth- ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. Methods : Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. Results : The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). Conclusion : It seems like that there is no evidence of association of preeclampsia with methylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.