골수이식에 있어 약제에 의한 신독성의 임상적 고찰 = Drug - induced Nephrotoxicity in Patients with Bone Marrow Transplantation골수이식에 있어 약제에 의한 신독성의 임상적 고찰

다국어 초록 (Multilingual Abstract)

We reviewed 38 cases of patients with bone marrow transplantation (BMT) and the results are as follows: 1) Thirty of thirty eight patients (82%) showed nephrotoxicity: 12 cases of electrolyte imbalance (31%), 2 cases (8%) of acute renal failure (ARF), and both, 16 cases (43%). 2) Incidence of ARF in Cyclosporin A (CsA) plus antimicrobial agents (AM) group, AM group and CsA group was 60%, 33% and 16% respectively. 3) The most common incidence of electrolyte imbalance was hypokalemia (26 cases, 70%), followed by hypocalcemia (14 cases, 38%), hypophosphatemia (10 cases, 27%), hyponatremia (5 cases, 13%), and hypomagnesemia (3 cases, 8%) 4) Clinical characteristics of patients with ARF were non-oliguric (2,867±481ml/24hrs), mildly azotemic (serum Cr: 2.2±0.6mg/dl), and reversible except one expired case. 5) The increase in serum creatinine was correlated with the duration of the administration of the nephrotoxic drugs (r=0.60, p<0.05). Though the impact of the nephrotoxic drugs could not be evaluated individually, it seems that, combined use of antimicrobial agents and CsA after BMT be the major factor of ARF.