유산소 운동과 케르세틴 섭취 및 저지방 식이 복합 처치가 비만 쥐 골격근의 지질대사, 미토콘드리아 생합성 및 염증성 싸이토카인에 미치는 효과

다국어 초록 (Multilingual Abstract)

The aim of this study was to compare the effectiveness of aerobic exercise training or quercetin supplementation with a low fat diet on lipid metabolism, mitochondrial biogenesis and inflammatory cytokine in skeletal muscle of high fat diet-induced obese mice. C57BL/6J mice(5 weeks old, n=28) were fed high fat diet (45 % fat) for 12 weeks first and then fed low fat diet for 8 weeks later. The mice were divided into 4 groups：low-fat diet control (HLC; n=7), low fat diet with quercetin(HLQ; n=7), low fat diet with exercise (HLE n=7) and low fat diet with exercise plus quercetin (HLEQ; n=7). The exercise groups (HLE, HLEQ) performed treadmill running for 30-60 min/day at 10-22 m/min, 0 % grade, 5 times/week for 8 weeks and the quercetin groups (HLQ, HLEQ) received a daily dose of quercetin (10 mg/kg of body weight), 5 days/week for 8 weeks. In the results, the low fat diet with exercise training was significantly reduced in body weight, Lee-index, and blood lipid profile. A lso, T he l ow f at d iet with e xercise training w as s ignificant improvements i n lipid m etab olism (FAS, ACC, L EPTIN, ACOX), mitochodrial biogenesis (PGC-1α, Tfam) and inflammatory cytokines (TNF-α, IL-6). In conclusion, low fat diet with exercise training has a positive effects to ameliorate the metabolic disturbance in obese mice. However, it seems that the effect of low fat diet with quercetin was limited in lipid metabolism, mitochondria biogenesis and anti-inflammatory cytokines.

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