담마진과 아토피 피부염에 대한 Astemizole의 치료 효과에 관한 연구 : 공동연구 Multicenter Trials = A Clinical Study of Astemizole in the treatment of Urticaria and Atopic Dermatitis

다국어 초록 (Multilingual Abstract)

Authors performed a clinical study to evalute the therapeutic effect of Astemizole on urticaria and atopic dermatitis.
Totally 88patients including 66 urticaria patients(acute urticaria, 16; chronic urticaria, 23; factitious urticaria, 27) and 22 atopic dermatitis patients were studied by oral administration of 10 ㎎ Astemizole tablet daily for 6 weeks.
The estimation of therapeutic effect was done by the measurement of duration until disappearance of symptoms(erythema, wheal and pruritus in acute and chronic urticaria; pruritus and dermographism in factitious urticaria; pruitus in atopic dermatitis).
The results were as follows:
1. Acute urticaria; The percentage of patients who showed therapeutic effect was 81.2%(excellent, 31.2% ; good, 37.5% ; fair, 12.5%). This was statistically significant in difference vs poor(p<0.01).
2. Chronic urticaria; The percentage of patients who showed therapeutic effect was 87.0%(excellent, 34.8% ; good, 43.5% ; fair , 8.7%). This was statistically significant in difference vs poor(p<0.01).
3. Factitious urticaria; The percentage of patients who showed therapeutic effect was 85.2%(excellent, 33.3% ; good, 40.7% ; fair, 11.2%). This was statistically significant in difference vs poor(p<0.01).
4. Atopic dermatitis; The percentage of patients who showed therapeutics effect was 81.8%(excellent, 36.4% ; good, 409% ; fair,4.5%). This was statistically significant in difference vs poor(p<0.01).
5. During the study, 11 patients observed side effects(sedation, 5; dry mouth, 4; gastric discomfort, 2).
Therefore we have impressed that Astemizole is an effective antihistamine which develop less side effects than other antihistamines for urticaria and atopic dermatitis.