한국인 침윤성 자궁경부암환자에 있어서의 HLA-A, -B 및 -C 항원 분포에 관한 연구 = HLA-A, -B and -C Antigen Frequency in Korean Patients with Invasive Carcinoma of the Cervix

다국어 초록 (Multilingual Abstract)

Abstract
It huts been suggested that HLA-linked genes may influence the development of malignant tumors or serve as a genetic tumor marker for come malignant tumors, be the studs of the association between HLA and malignant tumors may make possible more ideal therapeutic approaches to these tumors understanding of their genetic ·causes, and enable more accurate diagnosis.
In the present studs, it baa been attempted to survey the assocation of HLA-A, B and -C antigens in Korean patients with invasive carcinoma of the cervix.
HLA-A, -B and -C antigen typing was performed on 53 Korean patients with invasive carcinoma of the cervix, and the HLA-A and -B antigen frequencies of patients were compared with 214 healthy controls while the HLA-C antigen frequencies of patients were compared with 72 healthy controls. No statistically significant differences in the frequencies of the HLA-A, -B and -C antigens were observes. However, one of the patients had HLA-Bw21 antigen, which was not found in the controls.
Although this data from 53 patients with invasive carcinoma of the cervix is insufficient to give significant conclusions, if the immune response gene is a predisposing factor toward resistance or susceptibility against invasive carcinoma of the cervix, that gene is not strongly associated with any HLA-A, -B or -C antigens.

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 연구대상 및 방법
• A. 연구대상
• B. HLA-A, -B 및 -C항원 검사
• Ⅲ. 연구성적
• Ⅳ. 고안
• Ⅴ. 결론