Chloramphenicol 前處置量이 多量의 四鹽化炭素에 依한 急性中毒性 肝病變에 미치는 影響에 關한 病利組織學的 硏究 = Histopathological Studies on Effects of Pretreated Dosage of Chloramphenicol upon Acute Hepatic Lesions Induced by Large Amount of Carbon Tetrachloride

다국어 초록 (Multilingual Abstract)

Carbon tetrachloride, a potent hepatotoxic agents, is metabolized mainly in the liver, and its hepatotoxic action is influenced by the administration of chloramphenicol which is thought of an antagonist of metabolism in the liver.
Sprague-Dawley rats (male and female) were pretreated with 100 ㎎, 150 ㎎ and 200 ㎎ of 10% chloramphenicol saline solution per kilogram of body weight, and 30 minutes later were administered intraperitoneally, 5 ml of carbon tetrachloride(CCl_4) per kilogram of body weight after being anesthetized by ether.
Food was withheld 12 hours before chloramphenicol or physiological saline administration.
Controls received the equivalent amount of saline solution, and 30 minutes later 5ml/㎏ of the CCl_4.
At 3, 6, 12, 24, 48, 72, 96 hours after CCl_4 administration, 6 animals of each group were sacrified, and the histopathogical changes in the liver of the control and experimental groups were noted as follows;
1. Vacuolar degeneration of the hepatic cells of chloramphenicol pretreated rats showed more marked in degree than the control group.
2. Fatty change of 100 ㎎ chloramphenicol pretreated rats was more mild than the control group, and that of 150 ㎎ or 200 ㎎ group was similar to the control.
3. The necrotic changes of the hepatic cells of chloramphenicol pretreated rats were more mild than the control, and the degree of mildness is in order of pretreated dosage of chloramphenicol.
4. Regeneration of hepatic cells and sinusoidal cells, and reconstruction of the hepatic lobules in the chloramphenicol pretreated rats were more active in degree than those of the control, and those wee proportionate to pretreated chloramphenicol dosage.