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      Apo E Null mice에서 인삼 Ginsenosides (PD:PT = 1) 추출물의 지질개선 및 항산화 효과 = Hypolipidemic and Antioxidant Effects to Ginseng Extract (PD:PT = 1) in Apo E Null Mice

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      https://www.riss.kr/link?id=A82576686

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      다국어 초록 (Multilingual Abstract)

      Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong to damarane saponin which are separated into protopanaxadiol and protopanaxtriol. To evaluate the complex effect of ginsenoside in apo E null mice, ginseng extract were intraperioneally (i.p.) injected and provided high-cholesterol diet for 12 weeks. Ginseng extract came from were i.p. injected with dose of 100 ㎎/㎏/day for 4 weeks in the last experimental duration. Ginseng extract used experiment was abundant Rb1, Rc, Re, and Rg1 and PD:PT ratio was 1.2. The high-cholesterol diet induced liver damage was significantly reduced by ginseng extract. Results from plasma lipid profiles and atherogenic index were improved by ginseng extracts. The GE group significantly decreased plasma TG and TC by 73% and 61% compared to apo E (-/-) group. Also ginseng extract tend to decrease lipid profiles and lipidperoxidation contents in liver and heart. Ginseng extract with an abundant amount of Rg1 significantly suppressed the apoptosis induction of cardiac tissue. In conclusion, ginseng extract (PD:PT = 1) was improved lipid profiles and anti-oxidant effects.
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      Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong to damarane saponin which are separated into protop...

      Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong to damarane saponin which are separated into protopanaxadiol and protopanaxtriol. To evaluate the complex effect of ginsenoside in apo E null mice, ginseng extract were intraperioneally (i.p.) injected and provided high-cholesterol diet for 12 weeks. Ginseng extract came from were i.p. injected with dose of 100 ㎎/㎏/day for 4 weeks in the last experimental duration. Ginseng extract used experiment was abundant Rb1, Rc, Re, and Rg1 and PD:PT ratio was 1.2. The high-cholesterol diet induced liver damage was significantly reduced by ginseng extract. Results from plasma lipid profiles and atherogenic index were improved by ginseng extracts. The GE group significantly decreased plasma TG and TC by 73% and 61% compared to apo E (-/-) group. Also ginseng extract tend to decrease lipid profiles and lipidperoxidation contents in liver and heart. Ginseng extract with an abundant amount of Rg1 significantly suppressed the apoptosis induction of cardiac tissue. In conclusion, ginseng extract (PD:PT = 1) was improved lipid profiles and anti-oxidant effects.

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      목차 (Table of Contents)

      • ABSTRACT
      • 서론
      • 재료 및 방법
      • 결과
      • 고찰
      • ABSTRACT
      • 서론
      • 재료 및 방법
      • 결과
      • 고찰
      • 요약 및 결론
      • Literature cited
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      참고문헌 (Reference)

      1 황진택, "진세노사이드 Rd의 AMPK 및 PPAR 감마의 신호전달경로를 통한 항비만효과" 한국생물공학회 22 (22): 341-344, 2007

      2 성종환, "백삼 및 홍삼추출물이 고지방 식이 급여 흰쥐의 혈정 지질 함량에 미치는 영향" 고려인삼학회 28 (28): 33-38, 2004

      3 전보현, "고지방식으로 생육한 생쥐 간에서 백삼과 홍삼 추출물의 항산화 효과" 고려인삼학회 29 (29): 138-144, 2005

      4 Mayr M, "Vascular proteomics: linking proteomic and metabolomic changes" 4 (4): 3751-3761, 2004

      5 Gum SI, "The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[α]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs the potent protective effect of wild ginseng" 112 (112): 568-576, 2007

      6 Kim SS, "The effects on the blood lipid profiles and body fat by long term administration of red ginseng product" 26 (26): 67-73, 2002

      7 Yoon SH, "The effect of lithosperomi radixon benzo(a)pyrene-induced hepatotoxicity" 22 (22): 144-148, 1993

      8 Bartoli GM, "Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis" 966 (966): 214-221, 1988

      9 Jung NP, "Studies on the physiological and biochemical effects of Korean ginseng" 20 (20): 431-471, 1996

      10 Zhang SH, "Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E" 258 (258): 468-471, 1992

      1 황진택, "진세노사이드 Rd의 AMPK 및 PPAR 감마의 신호전달경로를 통한 항비만효과" 한국생물공학회 22 (22): 341-344, 2007

      2 성종환, "백삼 및 홍삼추출물이 고지방 식이 급여 흰쥐의 혈정 지질 함량에 미치는 영향" 고려인삼학회 28 (28): 33-38, 2004

      3 전보현, "고지방식으로 생육한 생쥐 간에서 백삼과 홍삼 추출물의 항산화 효과" 고려인삼학회 29 (29): 138-144, 2005

      4 Mayr M, "Vascular proteomics: linking proteomic and metabolomic changes" 4 (4): 3751-3761, 2004

      5 Gum SI, "The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[α]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs the potent protective effect of wild ginseng" 112 (112): 568-576, 2007

      6 Kim SS, "The effects on the blood lipid profiles and body fat by long term administration of red ginseng product" 26 (26): 67-73, 2002

      7 Yoon SH, "The effect of lithosperomi radixon benzo(a)pyrene-induced hepatotoxicity" 22 (22): 144-148, 1993

      8 Bartoli GM, "Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis" 966 (966): 214-221, 1988

      9 Jung NP, "Studies on the physiological and biochemical effects of Korean ginseng" 20 (20): 431-471, 1996

      10 Zhang SH, "Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E" 258 (258): 468-471, 1992

      11 Gottlieb RA, "Reperfusion injury induces apoptosis in rabbit cardiomyocytes" 94 (94): 1621-1628, 1994

      12 Liu CX, "Recent advances on ginseng research in China" 36 (36): 27-38, 1992

      13 Liu CX, "Recent advances on ginseng research in China" 36 (36): 27-38, 1992

      14 Cabral de Oliveira AC, "Protective effects of panax ginseng on muscle injury and inflammation after eccentrie exercise" 130 (130): 369-377, 2001

      15 Schraufstatter I, "Oxidantinduced DNA damage of target cells" 82 (82): 1040-1050, 1988

      16 J Searle, "Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance" 17 (17): 229-259, 1982

      17 Guo Y, "Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice" 208 (208): 54-67, 2005

      18 Zhou W, "Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease" 10 (10): 187-192, 2004

      19 Sengupta S, "Modulating angiogenesis: the yin and the yang in ginseng" 110 (110): 1219-1225, 2004

      20 Sandstrom PA, "Inhibition of activationinduced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis" 55 (55): 221-226, 1994

      21 Bardales RH, "In situ apoptosis assay for the detection of early acute myocardial infarction" 149 (149): 821-829, 1996

      22 Zhang JT, "Improvement of learning and memory and biphasic regulation of body temperature in mice induced by ginsenoside Rg1 and Rb. Proceedings of the 4th of China-Japan Symposium on Drug"

      23 Graeber TG, "Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours" 379 (379): 88-91, 1996

      24 Tanaka M, "Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes" 75 (75): 426-433, 1994

      25 W Ji, "Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats" 113 (113): 318-324, 2007

      26 Gordon T, "High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study" 62 (62): 707-714, 1977

      27 Lee HU, "Hepatoprotective effect of ginsenside Rb1 and compound K on tert-butyl hydroperoxide- induced liver injury" 25 (25): 1069-1073, 2005

      28 Kim YS, "Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2" 30 (30): 327-338, 1998

      29 Lu JP, "Ginsenoside Rg1-induced alterations in gene expression in TNF-α stimulated endothelial cells" 117 (117): 871-876, 2004

      30 Cho WC, "Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats" 550 (550): 173-179, 2006

      31 Vassault A, "Evaluation according to the NCCLS protocol of the Kodak-Ektachem procedure applied to the estimation of glucose and urea in plasma (author’s transl)" 39 (39): 17-28, 1981

      32 Lee MS, "Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage" 18 (18): 348-354, 2007

      33 Sievenpiper JL, "Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides" 23 (23): 248-258, 2004

      34 Ancion A, "Congestive heart failure and diabetes mellitus" 60 (60): 536-540, 2005

      35 Ancion A, "Congestive heart failure and diabetes mellitus" 60 (60): 536-540, 2005

      36 Noh YH, "Comparison of the effects of ginseng total saponin, ginsenoside-Rb1, ginsenoside-Rb2 and lovastatin on the expression of mRNAs for HMG CoA reductase and LDL receptor" 20 (20): 241-247, 1996

      37 Shibata S, "Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins" 14 (14): 595-600, 1966

      38 Fridovich I, "Biological effects of the superoxide radical" 247 (247): 1-11, 1986

      39 Kane DJ, "Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species" 262 (262): 1274-1277, 1993

      40 Hockenbery DM, "Bcl-2 functions in an antioxidant pathway to prevent apoptosis" 75 : 241-251, 1993

      41 J kajstura, "Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats" 74 (74): 86-107, 1996

      42 SC Joshi, "Antiatherogenic and antioxidant status of Panax ginseng in cholesterol ged rabbits. Proceedings of the 9th Int Ginseng Symposium" 25-28, 2006

      43 Xie JT, "Anti-diabetic effect of ginsenoside Re in ob/ob mice" 1740 : 319-325, 2005

      44 Wakabayashi C, "An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells" 246 (246): 725-730, 1998

      45 Gupta RK, "A comparative immunohistochemical study of splenic arterial hyalinosis in health and disease" 69 (69): 79-88, 1972

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-07-24 학술지명변경 한글명 : 한국영양학회지 -> Journal of Nutrition and Health
      외국어명 : The Korean Journal of Nutrition -> Journal of Nutrition and Health
      KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.86 0.86 1.03
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.18 1.11 1.778 0.12
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