癌患者의 血淸, 復水 및 肋膜渗出液이 健康人 淋巴球의 Rosette 形成에 미치는 影響 = Effects of Sera, Ascites and Pleural Effusions from Cancer Patients on the Rosstte Formation of Healthy Human Peripheral Blood Lymphocytes

다국어 초록 (Multilingual Abstract)

Advanced neoplastic disease has often been associated with a general imairment of such immune reponsivenesses as the delayed-type hypersensitivities measured by skin reactivity to certain antigens, the responses of lymphocytes to mitogens, and the spontaneous rosette formation of lymphocytes with sheep red blood cells(SRBC), However, the mechanisms which account for depressed lymphocyte function remain unclear. Recent studies have demonstrated the presence of the factors in sera, ascites and pleural effusions of patients with advanced cancer, which nonspecifically inhibit in vitro and in vivo lymphocyte function.
This study was undertaken to evaluae the effects of sera, ascites and pleural effusions from patients with cancers metastatic to peritoneum or pleura on the rosette forming abilities of healthy human peripheral blood lymphocytes. Sera from healthy person, roncancerous ascites and non-cancerous pleural effusions were used as controls.
Sera from gastric carcinoma, hepatcma and pulmorary carcinoma patients decreased the percentages of both early and late rosette forming lymphocytes and the affinities of lymphocytes to SRBC. Only serum from the hepatic cirrhosis patient among control patients decreased the percentages of rosette forming lymphocytes and the affinities of lymphocytes to SRBC.
Ascites from hepatoma patients and pleural effusions from pulmonary carcinoma patients decreased not only the percentages of early and late rosette forming lymphocytes severely but also the assinities of lymphocytes to SRBC.
On the other hand, ascites from gastric carcinoma patients increased the percentages of early rosette forming lymphocytes and the affinities of lymphocytes to SRBC. Control fluids exerted no effect on rosette formation except the pleural effeusions obtained from tuberculosis patients slightly increased the percentages of rosette forming lymphocytes and the affinities of lymphocytes to SRBC.