Applied virology

목차 (Table of Contents)

• CONTENTS
• Contributors = xv
• Preface = xix
• Introduction = xxi
• Ⅰ NEW VIRUS VACCINE TECHNOLOGY AND CHEMOTHERAPY
• 1 Strategy for Virus Vaccine Development / ERLING NORRBY
• Ⅰ. Introduction = 3
• Ⅱ. Choice of Viral Vaccines = 4
• Ⅲ. Live Virus Vaccines = 4
• Ⅳ. Categories of Vaccines containing Nonreplicating Antigens = 14
• Ⅴ. Conclusion = 14
• References = 14
• 2 Genetic Engineering Technology in Vaccine Production and Control of Animal Virus Diseases / F. A. MURPHY ; F. BROWN ; J. F. OBIJESKI
• Ⅰ. Introduction = 17
• Ⅱ. Genetic Engineering of Rabies Vaccine = 20
• Ⅲ. Genetic Engineering of Foot-and-Mouth Disease Vaccine = 24
• Ⅳ. Priorities for Genetic Engineering of Other Animal Vaccines = 27
• Ⅴ. Technology Transfer to Developing Countries References = 28
• References = 29
• 3 Location and Sequence of a Critical Antigenic Site on VP1 of Poliovirus Type 3 and Its Relevance to the Development of Novel Vaccines against Poliomyelitis / P. D. MINOR ; D. M. A. EVANS ; MORAG FERGUSON ; M. SPITZ ; J. W. ARMOND ; G. C. SCHILD
• Ⅰ. Introduction = 31
• Ⅱ. Antigenic Analysis of Poliovirus Using Monoclonal Antibodies = 32
• Ⅲ. Location and Primary Structure of the Antigenic Site for Neutralization of Poliovirus Type 3 = 39
• Ⅳ. Discussion and Conclusion = 45
• References = 48
• 4 Synthesis of Viral Membrane Protein in Bacillus subtilis / RALF F. PETTERSSON ; KENNETH LUNDSTR$$\ddot O$$M ; HENRIK GAROFF ; ILKKA PALVA ; LEEVIK$$\ddot A$$$$\ddot A$$RI$$\ddot A$$INEN ; NILS OKER-BLOM
• Ⅰ. Introduction = 51
• Ⅱ. Construction of a Secretion Vector for Expression of Foreign Genes in Bacillus subtilis = 55
• Ⅲ. Modification of the E1 Member Protein Gene of Semliki Forest Virus = 56
• Ⅳ. Joining of the E1 Gene to the Secretion Vector = 58
• Ⅴ. Expression of E1 in Bacillus subtilis = 58
• Ⅵ. Conclusions = 59
• References = 60
• 5 Production of Hepatitis-Safe Plasma Proteins from Cold Sterilized Plasma / W. STEPHAN
• Ⅰ. Introduction = 63
• Ⅱ. Cold Sterilization of Plasma = 64
• Ⅲ. Combination of Cold Sterilization and Adsorption = 66
• Ⅳ. Properties of Sterilized Factor Ⅸ Concentrate = 66
• Ⅴ. Properties of Stabilized Serum Biseko = 67
• References = 70
• 6 Factors Influencing the Performance of Foot-and-Mouth Vaccines under Field Conditions / THOMAS W. F. PAY
• Ⅰ. Introduction = 73
• Ⅱ. The Disease = 74
• Ⅲ. The Vaccine = 76
• Ⅳ. The Host = 77
• Ⅴ. The Human Element = 79
• Ⅵ. Graphic Models = 81
• Ⅶ. Discussion = 83
• References = 85
• 7 Progress in Antiviral Chemotherapy / G. J. GALASSO
• Ⅰ. Introduction = 87
• Ⅱ. Viral Vaccines = 88
• Ⅲ. Passive Immunization = 88
• Ⅳ. Antiviral Agents = 88
• Ⅴ. Conclusion = 100
• References = 102
• 8 Acyclovir: A Review of the Preclinical and Clinical Status / A. PAUL FIDDIAN
• Ⅰ. Introduction = 103
• Ⅱ. In Vitro Activity = 104
• Ⅲ. Mechanism of Action = 104
• Ⅳ. Animal Studies = 105
• Ⅴ. Pharmacokinetics in Man = 106
• Ⅵ. Clinical Experience = 107
• Ⅶ. Tolerance in Clinical Use = 113
• Ⅷ. Conclusion = 115
• References = 115
• Ⅱ PRESENT STATUS OF VACCINATION AGAINST VIRAL DISEASES
• 9 Worldwide and Differing Vaccinations against Human Viral Diseases / A. J. CLAYTON
• Ⅰ. Introduction = 123
• Ⅱ. Vaccine-Preventable Viral Diseases = 124
• Ⅲ. Individual Diseases = 125
• Ⅳ. Measles Eradication = 127
• Ⅴ. Conclusion = 129
• References = 130
• 10 Principal Human Viral Diseases: Present Status of Vaccination / T. A. BEKTIMIROV ; F. ASSAAD
• Ⅰ. Introduction = 131
• Ⅱ. Measles = 132
• Ⅲ. Poliomyelitis = 136
• Ⅳ. Viral Hepatitis = 144
• Ⅴ. Rabies = 148
• Ⅵ. Yellow Fever = 153
• References = 157
• 11 Present Status of Vaccination against Poliomyelitis in the African Region of the World Health Organization / C. ALGAN
• Ⅰ. Introduction = 159
• Ⅱ. Epidemiology of Poliomyelitis = 160
• Ⅲ. Expanded Program of Immunization(EPI) = 164
• Ⅳ. Principal EPI Achievements = 166
• Ⅴ. Conclusion = 167
• References = 168
• 12 Hepatitis B Virus: Approaches to Control and Vaccination / COLIN R. HOWARD ; ARIE J. ZUCKERMAN
• Ⅰ. Introduction = 171
• Ⅱ. Immunochemical Properties of Hepatitis B Surface Antigen = 172
• Ⅲ. Nature of the Hepatitis B Genome and Molecular Cloning Studies = 178
• Ⅳ. Chemically Synthesized Hepatitis B Vaccines = 182
• Ⅴ. Hepatitis B Surface Antigen from Heteroploid Cell Lines = 186
• References = 187
• 13 Vaccination of Newborns against Hepatitis B / F. DEINHARDT ; W. JILG ; R. ZACHOVAL ; J. ABB ; M. ROGGENDORF ; G. ZOULEK
• Ⅰ. Development of Vaccines against Hepatitis B = 191
• Ⅱ. Efficacy of Vaccines = 192
• Ⅲ. Indications for Vaccination = 193
• Ⅳ. Passive-Active Immunization = 193
• References = 196
• 14 Hepatitis B Vaccine and the Developing World / ALFRED M. PRINCE
• Ⅰ. Introduction = 199
• Ⅱ. Basis for a Need for Mass Immunization in High-Prevalence Regions = 200
• Ⅲ. Approaches to Prevention = 202
• Ⅳ. Conclusion = 207
• References = 207
• 15 Measles: A Continuing Problem or Eradication? / RAYMOND G. MARUSYK
• Ⅰ. Introduction = 211
• Ⅱ. The Virus = 212
• Ⅲ. The Disease = 213
• Ⅳ. The Problem = 214
• Ⅴ. The Control of Measles = 216
• Ⅵ. The Eradication of Measles = 216
• Ⅶ. Comments = 218
• References = 218
• 16 Rubella Revaccination: Will It Be Necessary? / JENNIFER M. BEST ; SIOBHAN O'SHEA ; J. E. BANATVALA
• Ⅰ. Introduction = 221
• Ⅱ. Materials and Methods = 222
• Ⅲ. Results = 223
• Ⅳ. Discussion = 227
• References = 230
• 17 Rabies Enigma: Human and Animal Disease Control / ROBERT E. SHOPE
• Ⅰ. Introduction = 231
• Ⅱ. Present Problem of Rabies in the Middle East and Africa = 232
• Ⅲ. History of Rabies Control in the Middle East and Africa = 233
• Ⅳ. World Health Organization Program for Global Elimination of Rabies = 234
• Ⅴ.Considerations Related to Rabies Control = 234
• References = 239
• 18 Rabies Vaccine Produced in Cell Culture: Production Control and Clinical Results / M. ROUMIANTZEFE ; N. AJJAN ; R. BRANCHE ; P. FOURNIER ; B. MONTAGNON ; P. TROTEMANN ; J. C. VINCENT-FALQUET
• Ⅰ. Introduction = 241
• Ⅱ. Traditional Vaccines = 242
• Ⅲ. Human Diploid Cell Strain Vaccine = 246
• Ⅳ. Other Cell Culture Vaccine = 281
• Ⅴ. Conclusion = 288
• References = 289
• Ⅲ EPIDEMIOLOGY AND DIAGNOSIS OF VIRAL DISEASES
• 19 Epidemiology and Diagnosis of Viral Hemorrhagic Fevers / G. VAN DER GROEN
• Ⅰ. Introduction = 299
• Ⅱ. Epidemiology = 300
• Ⅲ. Diagnosis = 317
• Ⅳ. Conclusions = 322
• References = 322
• 20 Structure and Variation among Arenaviruses / COLIN R. HOWARD ; P. R. YOUNG
• Ⅰ. Introduction = 327
• Ⅱ. Natural History and Distribution = 328
• Ⅲ. Morphology and Ultrastructure = 332
• Ⅳ. Serological Relationship = 336
• References = 339
• 21 Diarrhea Viruses: Diagnosis as Prerequisite for Epidemiological Study / T. H. FLEWETT
• Ⅰ. Worldwide Problem = 343
• Ⅱ. WHO Diarrheal Diseases Control Program = 343
• Ⅲ. Diagnosis Methods = 344
• Ⅳ. ELISA Test = 346
• Ⅴ. Other Methods = 346
• Ⅵ. Subgrouping and Serotyping of Rotaviruses = 346
• Ⅶ. Electrophoresis of Rotavirus RNA Genomic Segments = 347
• References = 348
• 22 Virus-Induced Gastroenteritis in Animals / LORNE A. BABIUK
• Ⅰ. Introduction = 349
• Ⅱ. Agents Involved = 351
• Ⅲ. Diagnosis = 354
• Ⅳ. Pathology and Pathophysiology of Enteric Virus Infections = 355
• Ⅴ. Mixed Infections = 357
• Ⅵ. Immunity and Immunological Control of Gastroenteric Virus Infections = 358
• Ⅶ. Economic Impact of Neonatal Disease in Animals = 360
• Ⅷ. Conclusions = 361
• References = 361
• 23 Viral Hepatitis A: Virus, Disease, and Control / F. DEINHARDT ; J. ABB ; V. GAUSS-M$$\ddot U$$LLER ; K. VON DER HELM ; M. ROGGENDORF ; R. SCHEID
• Ⅰ. Introduction = 377
• Ⅱ. Characteristics of Hepatitis A Virus = 367
• Ⅲ. Disease = 369
• Ⅳ. Diagnosis = 370
• Ⅴ. Transmission and Epidemiology of Hepatitis A = 371
• Ⅵ. Prevention = 373
• Ⅶ. Treatment = 374
• Ⅷ. Hepatitis A-Like Epidemic Hepatitis Non-A, Non-B = 375
• Ⅸ. Conclusion = 375
• References = 375
• 24 Impact of Arthropod-Borne Virus Diseases on Africa and the Middle East / THOMAS P. MONATH
• Ⅰ. Introduction = 377
• Ⅱ. Yellow Fever = 379
• Ⅲ. Rift Valley Fever = 384
• Ⅳ. West Nile Fever = 389
• Ⅴ.Sindbis Virus Disease = 391
• Ⅵ. Chikungunya = 392
• Ⅶ. O'Nyong Nyong = 394
• Ⅷ. Dengue = 396
• References = 398
• 25 Congenital Viral Infections and Malformations: Problem, Prophylaxis, and Diagnosis / P. D. GRIFFITHS ; W. AL-NAKIB
• Ⅰ. Introduction = 402
• Ⅱ. Rubella = 403
• Ⅲ. Cytomegalovirus = 407
• Ⅳ. Varicella-Zoster Virus = 412
• Ⅴ. Influenza = 414
• Ⅵ. Laboratory Diagnosis of Infection = 416
• References = 426
• 26 Viral-Bacterial Synergistic Interactions in Respiratory Infections / LORNE A. BABIUK
• Ⅰ. Introduction = 431
• Ⅱ. Bacterial Adherence = 432
• Ⅲ. Experimental Models = 434
• Ⅳ. Virus-Induced Immunosuppression = 435
• Ⅴ. Injury to Lungs via Inflammatory Processes = 439
• Ⅵ. Impact of Viral-Bacterial Infections = 439
• Ⅶ. Conclusion = 440
• References = 441
• 27 Importance and Control of Fish and Mollusk Viruses / BRUCE L. NICHOLSON
• Ⅰ. Introduction = 445
• Ⅱ. Fish Viruses = 446
• Ⅲ. Mollusk Viruses = 454
• Ⅳ. Detection and Identification of Fish Viruses = 455
• Ⅴ. Cell Cultures = 457
• Ⅵ. Control of Viral Diseases of Fish and Shellfish = 459
• References = 460
• 28 Recent Advances in Immunodiagnosis of Viral Diseases of Crops / M. H. V. VAN REGENMORTEL
• Ⅰ. Introduction = 463
• Ⅱ. Newly Described Viruses = 464
• Ⅲ. Precipitation and Agglutination Methods = 465
• Ⅳ. Enzyme-Linked Immunosorbant Assay(ELISA) = 467
• Ⅴ. Immunosorbant Electron Microscopy(ISEM) = 470
• Ⅵ. Monoclonal Antibodies = 472
• References = 474
• 29 Enzyme Immunoassays Applied in Virology: Reagent Preparation and Interpretation / E. KURSTAK ; P. TIJSSEN ; C. KURSTAK
• Ⅰ. Introduction = 480
• Ⅱ. Conjugation Procedures = 482
• Ⅲ. Solid-Phase Immobilization = 488
• Ⅳ. Enzyme Immunoassays: Titration Procedures = 489
• Ⅴ. Identification and Localization Procedures = 491
• Ⅵ. Processing of Results = 494
• Ⅶ. Immunodiagnosis of Virus Infections Using Enzyme Tracers: Problems and Interpretation = 495
• Ⅷ. Conclusions = 499
• Ⅸ. Appendix = 502
• References = 502
• Index = 505