만성정신분열병의 양성 및 음성증상에 대한 Lithium의 항정신병 효과 = Antipsychotic Effects of Lithium on Positive and Negative Symptoms of Chronic Schizophrenia

다국어 초록 (Multilingual Abstract)

The authors investigated the antipsychotic effect of lithium in 24 chronic refractory schizophrenics with special interest in it's effects on positive and negative symptoms by a method of placebo controlled double-blined cross-over study.
Subjects were divided into two sequences:
Sequence 1 was Base-Lithium(4wks) -Placebo(4wks) -Lithium(4wks), and Sequence 2
was Base-Placebo(4wks) -Lithium(4wks) -Placebo(4wks). 24 schizophronics, diagnosed according to DSM-Ⅲ-R, were randomly assigned to each sequences so that each sequence had the same number of patients.
SAPS(Scale for the assessment of positive symptoms) and SANS(Scale for the
assessment of negative symptoms) were used for the assessment of the subjects's
mental status.
l) 9 of 24 Subjects(31% ) belonged to lithium-responder group : and others to lithium non-responder group.
2) In 9 lithium-responders, statistically significant improvement was noticed in “severity of hallucination as positive" symptom and in - “alogia” as negative symptom.
3) “Clothing & appearnce" among positive symptoms and “inappropriate affect" and “subjective complaint of inattentiveness" among negative symptoms changed
statistically significantly in all subjects(N -24)
All global ratings did not change significantly after lithium treatment.