자발두개내저압의 진단 지연 = Diagnostic Delay in Spontaneous Intracranial Hypotension

다국어 초록 (Multilingual Abstract)

Background: Spontaneous intracranial hypotension (SIH) develops a headache caused by cerebrospinal fluid (CSF) leakage without known cause of procedure or trauma to meninges. The purpose of this study was to investigate the time interval from symptom onset to diagnosis and the relevant factors of diagnostic delay in patients with SIH.
Methods: We analyzed the medical records of three hospitals patients diagnosed with SIH between January 2011 and January 2022. We collected information on the demographics, interval from symptom onset to diagnosis, and clinical features. Subjects with an interval from symptom onset to diagnosis in the third or higher quartiles among patients with SIH were defined as the delayed diagnosis group.
Results: This study included 131 patients with SIH. The mean interval from symptom onset to diagnosis was 20.1±37.8 days (interquartile range: 3.0-21.0). One hundred and seventeen patients (89.3%) had orthostatic headache.
Without orthostatic headache (odds ratio=5.43, 95% confidence interval=1.40-21.08) in clinical symptoms was an increased risk of delayed diagnosis of SIH.
Conclusion: In this study, about one-tenth of SIH patients did not present orthostatic headache. Without orthostatic headache was an associated factor of delayed diagnosis in SIH.