양전자 방출 단층촬영 검사에서의 흉곽내 비악성 FDG 집적 = Non-Malignant 18F-FDG Uptake in the Thorax by Positron Emission Tomography Computed Tomography Fusion Imaging

다국어 초록 (Multilingual Abstract)

Fluorine-18 2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET) has been used exclusively to diagnose malignancies. However, increased FDG uptake is not always limited to malignant tissue. Many false positive findings for PET have been reported. Moreover, the use of PET/CT may allow the reassessment of previously recognized patterns of physiological bio-distribution of a tracer. In this report we demonstrate the physiological FDG uptake of normal structures in the thorax using PET/CT imaging and illustrate many benign pathological conditions with standardized uptake values greater than 2.5.

국문 초록 (Abstract)

지금까지 악성 질환의 진단에 18FDG-양전자 방출 단층촬영 검사(PET)가 널리 쓰이고 있다. 그러나 PET에서 FDG 집적이 반드시 악성 조직에서만 이루어지는 것이 아니며 이는 지금까지의 여러 연구결과를 통해 알려졌다. 이후 PET/CT의 개발 덕분에 FDG의 생체 내 생리학적 분포에 대해서 알려지게 되었고, 따라서 이전에 PET만으로 설명할 수 없었던 FDG 집적에 관한 재분석이 이루어졌다. 이에 저자들은 PET/CT를 통하여 흉곽 내에의 정상구조물에 의한 정상적인 FDG 집적과 정상구조물의 생리학적 변화로 인한 FDG 집적 그리고 마지막으로 양성질환에 의한 FDG 집적의 예들을 열거하고자 한다.

참고문헌 (Reference)

1 "et al. Proceedings of a national cancer institute workshop PET in oncology" 604-606,

2 "Thymic en-largement and FDG uptake in three patients: CT and FDGpositron emission tomography correlated with pathology" 180 : 519-522, 2003

3 "The fusion of anatomic and physiologic imaging in the manage-ment of patients with cancer" 31 : 191-205, 2001

4 "Pulmonarytuberculoma evaluated by means of FDG PET: findings in 10 cases" 216 : 117-121, 2000

5 "Principles and practice of positron emission tomography" Philadelphia:Lippincott Williams & Wilkins 381-394, 2002

6 "Patterns of 18F-FDG uptake in adipose tissue and muscle: a poten-tial source of false-positives for PET" 44 : 1789-1796, 2003

7 "Normal variants in FDG PET imaging" Philadelphia: Lippincott Williams & Wilkins 111-136, 2002

8 "Clinical role of FDG PETin evaluation of cancer patients" 23 : 315-340, 2003

9 "Artifacts and normal variants in PET imaging" London: Springer 495-505, 2003

10 "Accuracy of positron emission tomography for diagnosis of pul-monary nodules and mass lesions; a meta-analysis" 285 : 914-924, 2001