벌유충 분말 서플리먼트의 이명에 대한 임상적 연구 = A clinical study for effect of a supplement(Bee Larva) in subjects with tinnitus

다국어 초록 (Multilingual Abstract)

Objectives : The primary purpose of present study is to evaluate the effect of a supplement of Bee Larva on tinnitus. the second is to comparatively evaluate safety of this supplement. Methods : Among those patients who visited Semyung Oriental Medical Center from January 11st, 2010 to February 20th, 2010, we screened 45 patients considered suitable for this study after some examinations and consent of the patients. they were devided into 2 groups. Group A took 5 tablets of this supplement everyday for 4 weeks, group B, placebo, in the same way. for 4 weeks, we checked changes in intensity, duration, extent of tinnitus on daily life and sleep and THI(Tinnitus Handicap Inventory) score. to evaluate safety of this supplement, adverse events, assessment of vital sign, hematologic examination were recorded. Result : Through 4 weeks of the clinical trial, we found that this supplement is effective on tinnitus and it improves intensity, duration and extent (its influence on daily life) of tinnitus, influence of tinnitus on sleep and THI score more effectively than the placebo drug. Also, in the assessment of the safety of the study the supplement of bee Larva and placebo drug, there were no adverse events and side effects over the average which need treatment for it. Moreover, there were not any abnormal findings in change of blood pressure and hematologic examination. Conclusion : According to this experiment, we confirmed that the supplement of bee Larva can be used effectively and safely on tinnitus.

참고문헌 (Reference)

1 김지혜, "한국어 번역판 Tinnitus Handicap Inventory의 신뢰도 및 타당도 연구" 대한이비인후과학회 45 (45): 328-334, 2002

2 박시내, "이명재훈련치료의 적용 방법과 치료 효과" 대한이비인후과학회 45 (45): 231-237, 2002

3 백무진, "이명의 청각학적 진단" 대한이비인후과학회 부산,울산,경남 지부회 22 (22): 44-49, 2011

4 전경명, "이명의 자각적 표현과 주파수의 관계" 대한이비인후과학회 48 (48): 961-966, 2005

5 정연훈, "이명에 대한 Glutamate 길항제의 치료효과" 대한이비인후과학회 46 (46): 935-939, 2003

6 황준연, "이명 환자에서 경구 약물 치료에 병행한 Lasix-Vitamin-Dextran정맥 주사 및 Carbogen 흡입 요법의 치료 효과" 대한이비인후과학회 49 (49): 269-273, 2006

7 이호기, "이명 재훈련 치료에서의 지도 상담의 효과" 대한이비인후과학회 47 (47): 217-221, 2004

8 이승준, "노인 환자에서 이명에 대한 주파수 분석과 난청과의 관계" 대한이비인후과학회 50 (50): 869-875, 2007

9 Bernhard Kellergals, "Tinnitus rehabiliation by retraining" Editor 13-90, 2003

10 Ferreira PEA, "Tinnitus handicap inventory: cross-cultural adaptation to Brazilian Portuguese" 17 (17): 303-310, 2005

11 Mun BW, "Study on tinnitus treated with acupuncture" 12 (12): 317-321, 1995

12 Sinmoonnongchulpangongsa, "Sinpyeonjungyakdasajun" Sinmoonnongchulpangongsa 2383-, 1971

13 Jin Sil Gong, "Silyongjoongeuigyulhapjindanchiryohak" Iljoongsa 1909-1910, 1992

14 Newman CW, "Psychometric adequacy of the Tinnitus Handicap Inventory(THI)for evaluating treatment cotcome" 9 : 153-160, 1998

15 Korean Society of Otorhinolaryngology-Head and Neck Surgery, "Otorhinolaryngology" Ilchokak 177-188, 2005

16 Hwang JO, "New approach to treat tinnitus" 32-34, 1997

17 Oh Guk Jung, "Naegyeongjindanhak" Daesungmoonhwsa 202-, 1983

18 Baek MJ, "Handicap of Tinnitus and Quality of Life in Tinnitus Patients" 13 (13): 50-55, 2002

19 Jang Gae Bin, "Gyeongakjeonseo" Daesungmoonhwsa 566-570, 1998

20 Murai K, "Examination of tinitius" 22 : 54-66, 1992

21 Chon KM, "Diagnosis and treatment of tinnitus" 7 : 326-339, 1996

22 Newman CW, "Development of the Tinnitus Handicap Inventory" 122 : 143-148, 1996

23 Chae BY, "Clinical study of therapy on the Tinnitus" 7 (7): 109-111, 1986

24 Seo HS, "Clinical study in52 cases of patients with tinnitus" 8 (8): 39-49, 1999

25 Sullivan MD, "A Randomized trial of nortriptyline for severe chronic tinnitus" 153 (153): 2251-2259, 1993