Platinum complexes having 7-membered ring structure with N,N'-bis(2-hy-droxyethyl)butylenediamine(HeBn) and N,N'-bis(2-chloroethyl)butyelenediamine(CeBn) as carrier ligands were synthesized to enhance antitumor activity and to decrease the toxicity. P...
Platinum complexes having 7-membered ring structure with N,N'-bis(2-hy-droxyethyl)butylenediamine(HeBn) and N,N'-bis(2-chloroethyl)butyelenediamine(CeBn) as carrier ligands were synthesized to enhance antitumor activity and to decrease the toxicity. Platinum complexes were prepared by reacting K_2PtI_4 with HeBn or CeBn. IR, NMR, elementary analysis, ICP-AES and titration method were applied for identification and analysis of the synthesized platinum complexes.