캐모마일(Matricaria chamomilla L.)의 생리활성

국문 초록 (Abstract)

캐모마일(Matricaria chamomilla L.)을 성인병 예방을 위한 기능성 식품 소재로 이용하기 위하여 추출물의 생리활성 효과를 조사하였다. 추출물의 phenol 함량은 열수추출물이 23.64±0.35 ㎎/g이었으며, 60% 알콜추출물은 24.98±0.20㎎/g으로 60% 알콜추출물의 phenol 함량이 다소 높게 나타났다. 캐모마일의 HPLC 분석 결과 생리활성 효과가 높은 rosemarinic acid, quercetin의 함량이 많은 것으로 보아 생리활성 효과가 있을 것으로 사료된다. 각 추출물의 항산화 효과는 DPPH가 열수추출물과 60% 알콜추출물이 각각 91.05%와 95.49%로 높게 나타났고, antioxidant protection factor (PF)는 열수추출물이 0.71±0.02로 지용성 물질에 대한 항산화력은 낮았으나, 60% 알콜추출물은 1.48±0.03으로 높은 PF를 나타내어 열수추출물보다는 60% 알콜추출물이 지용성에 대한 항산화력이 더 높다는 것을 알 수 있었다. Helicobater pylori에 대한 추출물의 항균활성은 열추추출물의 경우 clear zone이 나타나지 않았으며, 60% 알콜추출물의 경우 200 ㎍/mL의 농도일 때 9.42 ㎜의 clear zone이 관찰되어 60% 알콜추출물에서만 낮은 저해활성이 있는 것으로 판단되었다. ACE 저해효과는 열수추출물이 87.98%, 60% 알콜추출물이 91.36%의 저해효과를 나타내어 높은 고혈압 효과를 나타내었다. XOase에 대한 억제효과는 열수추출물이 73.48%, 60% 알콜추출물이 81.96%의 저해효과를 나타내어 XOase에 대한 높은 저해를 관찰할 수 있었다. 이러한 결과로 캐모마일의 60% 알콜추출물이 항산화제, 고혈압 및 항관절염 소재로의 개발이 기대되어었다.

다국어 초록 (Multilingual Abstract)

The biological activity of water and ethanol extracts from Chamomaile for functional food source were examined. Total phenol contents in the 60% ethanol extracts (24.98±0.20 ㎎/g) from Chamomaile leaf was higher than those of water extracts (23.64±0.35 ㎎/g). The major phenolic compound by HPLC were rosemarinic acid and quercetin. 60% ethanol extracts had higher content of these phenolics than water extacts. Electron donating ability showed 91.05% in the water extracts and 95.49% in the 60% ethanol extracts. Antioxidant protection factor (PF) showed 0.71±0.02 in the water extracts and 1.48±0.03 in the 60% ethanol extracts. The water extracts of Chamomaile leaves did not have antimicrobial activity against H. pylori, but the 60% ethanol extracts revealed the slight antimicrobial activity as 9.42 mm of clear zone. Angiotensin converting enzyme inhibition was 57.98% in water extracts and 91.36% in 60% ethanol extracts. Xanthine oxidase activity was 73.48% in water extracts and 81.96% in 60% ethanol extracts. The results suggest that Chamomailes extract may be useful as potential source as antioxidant, angiotensin converting enzyme and xanthine oxidase inhibitors.

목차 (Table of Contents)

• Abstract
  
• 서론
  
• 재료 및 방법
  
• 결과 및 고찰
  
• 요약
  
• 감사의 글
  
• 문헌

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