Pentoxifylline과 고압산소요법이 백서 무축 피판 생존율에 미치는 영향 = The Effects of Pentoxifylline and Hyperbaric Oxygen on the Survival Rate of the Random Pattern Skin Flaps in Rats

다국어 초록 (Multilingual Abstract)

The effects of pentoxifylline, hyperbaric oxygen and combination of the two on the survival rate of random pattern skin flaps were evaluated in an experimental study in rats.
Thirty-five rate were divided into five groups. Cephalic based random pattern flaps were designed on the back of the rats and control group animals received twice-daily an intraperitoneal injection of 1cc normal saline solution for seven days before surgery and every 12 hours after the operation for seven days and to control for the stress of injection. Group I rats were treated with pentoxifylline received 20 ㎎/kg intraperitoneally at 24, 12, and 1 hour(s) before flap elevation and every 12 hours after the operation for seven days. Group Ⅱ rats were treated with twicedaily pentoxifylline injections for seven days before surgery and were then managed as Group I. Group Ⅲ rats were treated with hyperbaric oxygen within four hours after flap operation. Group Ⅳ rats were given exactly as Group Ⅱ and Group Ⅲ.
The survival rate to the total flap was calculated.
The results were as follows:
1. The mean survival rate of the flaps was 54.60±16.78% in control, 61.34±10.62% in group I, 64.96±3.08% in group Ⅱ, 71.93±9.26% in group Ⅲ, 86.67±8.17% in group Ⅳ.
2. The survival rate of the flaps were increased in group Ⅰ,Ⅱ, Ⅲ, Ⅳ when compared with the control group.
3. The combination of pentoxifylline and hyperbaric oxygen showed synergistic effect on the survival rate of the flap.
4. In the histopathologic study at postoperative 7th day, abundant proliferation of fibroblast and capillary blood vessels were observed in the experimental Ⅲ group, while severe infiltration of inflammatory cells were observed in the control group.