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      SCIE SCOPUS KCI등재

      Oncogenic Pathways of Mitogen-activated Protein Kinases and Phosphatidylinositol 3-kinase in Epithelial Ovarian Cancer

      한글로보기

      https://www.riss.kr/link?id=A40034713

      • 저자

        Jeung, Eui-Bae (Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;  Park, Se-Hyung (Department of Obstetrics and Gynaecology, BC Research Institute Children's and Women's Health,University of British Columbia) ;  Leung, Peter C.K. (Department of Obstetrics and Gynaecology, BC Research Institute Children's and Women's Health,University of British Columbia) ;  Yang, Hoe-Saeng (Department of Obstetrics and Gynaecology, College of Medicine, Dongguk University) ;  Sim, Jae-Chul (Department of Obstetrics and Gynaecology, College of Medicine, Dongguk University) ;  Kim, Kyung-Tai (Department of Obstetrics and Gynaecology, College of Medicine, Hanyang University) ;  Choi, Kyung-Chul (Department of Obstetrics and Gynaecology, BC Research Institute Children's and Women's Health,University of British Columbia, Department of Obstetrics and Gynaecology, University of British Columbia)

      • 발행기관
      • 학술지명
      • 권호사항
      • 발행연도

        2003

      • 작성언어

        English

      • 주제어
      • KDC

        516.000

      • 등재정보

        SCIE,SCOPUS,KCI등재

      • 자료형태

        학술저널

      • 발행기관 URL
      • 수록면

        290-299(10쪽)

      • 제공처
      • 중단사유

        ※ 발행기관의 정책으로 인하여 개인 판매가 중단된 논문입니다. 구독기관 이용자는 [유료 KISS] 홈페이지에서 원문을 이용해 주시기 바랍니다.

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      다국어 초록 (Multilingual Abstract)

      Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. The chemotherapeutic agents, growth factors and reproductive hormones have been demonstrated to activate MAPKs, suggesting that the MAPK signaling pathway plays an important role in the regulation of proliferation, apoptosis, survival and differentiation in response to these external stimuli in ovarian cancer. In addition to MAPKs as an oncogenic pathway, phosphatidylinositol 3-kinase (PI3K) plays a role in a various range of important cellular processes associated with malignant characterestics including cell growth, survival and migration, which is a member of lipid kinases subfamily that phosphorylates and dephosphorylates the 3-position of the inositol ring of phosphoinositides in a membrane. In this review, recent results of the MAPK and PI3K signaling cascades by external stimuli, and potential roles of these oncogenic pathways as an oncogenic pathway are summarized in epithelial ovarian cancer.
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      Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. The chemotherapeutic a...

      Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. The chemotherapeutic agents, growth factors and reproductive hormones have been demonstrated to activate MAPKs, suggesting that the MAPK signaling pathway plays an important role in the regulation of proliferation, apoptosis, survival and differentiation in response to these external stimuli in ovarian cancer. In addition to MAPKs as an oncogenic pathway, phosphatidylinositol 3-kinase (PI3K) plays a role in a various range of important cellular processes associated with malignant characterestics including cell growth, survival and migration, which is a member of lipid kinases subfamily that phosphorylates and dephosphorylates the 3-position of the inositol ring of phosphoinositides in a membrane. In this review, recent results of the MAPK and PI3K signaling cascades by external stimuli, and potential roles of these oncogenic pathways as an oncogenic pathway are summarized in epithelial ovarian cancer.

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