내분비계 장애추정농약에 대한 에스트로겐성 영향검색 및 위해성 평가

다국어 초록 (Multilingual Abstract)

The present study was conducted to test and evaluate estrogenic effect of 17 pesticides including benomyl and carbaryl, being suspected as endocrine disrupting chemicals. For estrogenic effect examination, luciferase assay were achieved with human ovarian cancer cell, BG1Luc4E2. Estrogenic effects of cypermethrin, dicofol, endosulfan, esfenvalerate, and fenvalerate were observed at the concentration of 10??, M by estrogen receptor binding assay. Relative luciferase potency and relative luciferase effects compared with 10?¹? M 17 β-estradiol were 10??, 56% for dicofol, and 10??, 72% for endosulfan, respectively. Estimated maximum daily intake for pesticides was calculated from maximum residue limit of agricultural commodity and food consumption was 1.2298 ㎎/person. Theoretically calculated blood estrogen level from dietary intake for pesticides based on MRL in Korea, 3.075 ng/ℓ was equivalent to 15% of estrogen concentration in normal blood, but practical monitoring data, 0.01938 ng/ℓ, was equal to 0.09693% of estrogen concentration in normal blood.

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