비미란성 역류 질환 = Nonerosive Reflux Disease

다국어 초록 (Multilingual Abstract)

Nonerosive reflux disease (NERD) is a distinct presentation of gastroesophageal reflux disease (GERD). NERD is commonlydefined as the presence of classical GERD symptoms in the absence of esophageal mucosal erosions/breaks on upper endoscopy. Within the spectrum of GERD, the pathophysiological and clinical characteristics distinguishing NERD and erosive esophagitis remaina matter for debate. Recent research on NERD has focused on understanding the pathophysiology and natural history. Giventhe increased incidence of NERD in Korea, we reviewed the concept of NERD and its relationship to GERD and functional gastrointestinaldisorders.

참고문헌 (Reference)

1 이준행, "위식도역류질환의 치료에 관한 임상진료지침" 대한소화기학회 57 (57): 57-66, 2011

2 조유경, "위식도역류질환의 진단: 체계적인 문헌고찰" 대한소화기학회 55 (55): 279-295, 2010

3 이준행, "위식도 역류질환의 내시경 진단에서 관찰자 간 차이" 대한소화기내시경학회 33 (33): 197-203, 2006

4 황진기, "국내 2-3차 의료기관에서 관찰된 미란 식도염의 유병률 및 증상 분포" 대한소화기학회 53 (53): 283-291, 2009

5 유승석, "건강진단검사 수진자에서 식도질환의 유병률" 대한소화기학회 50 (50): 306-312, 2007

6 Gerson LB, "Triadafilopoulos G. A cost-effectiveness analysis of prescribing strategies in the management of gastroesophageal reflux disease" 95 : 395-407, 2000

7 El-Serag HB, "Time trends of gastroesophageal reflux disease:a systematic review" 5 : 17-26, 2007

8 Kim N, "The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea" 27 : 173-185, 2008

9 Drossman DA, "The functional gastrointestinal disorders and the Rome II process" 45 (45): II1-II5, 1999

10 Shapiro M, "The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups" 23 : 321-329, 2006

11 Fass R, "Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease–where next?" 22 : 79-94, 2005

12 Drossman DA, "Rome III: new standard for functional gastrointestinal disorders" 15 : 237-241, 2006

13 Emerenziani S, "Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non-erosive reflux disease" 21 : 253-258, 2009

14 Ho KY, "Reflux esophagitis patients in Singapore have motor and acid exposure abnormalities similar to patients in the Western hemisphere" 94 : 1186-1191, 1999

15 Labenz J, "Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease" 101 : 2457-2462, 2006

16 Heading RC, "Prevalence of upper gastrointestinal symptoms in the general population: a systematic review" 231 : 3-8, 1999

17 Mishima I, "Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese" 40 : 1005-1009, 2005

18 Locke GR 3rd, "Prevalence and clinical spectrum of gastroesophageal reflux:a population-based study in Olmsted County, Minnesota" 112 : 1448-1456, 1997

19 Hirano I, "Practice Parameters Committee of the American College of Gastroenterology" 102 : 668-685, 2007

20 Frazzoni M, "Pathophysiological characteristics of the various forms of gastro-oesophageal reflux disease: Spectrum disease or distinct phenotypic presentations?" 38 : 643-648, 2006

21 Lind T, "On demand therapy with omeprazole for the long-term management of patients with heartburn without oesophagitis-a placebo-controlled randomized trial" 13 : 907-914, 1999

22 Martinez SD, "Non-erosive reflux disease (NERD)-acid reflux and symptom patterns" 17 : 537-545, 2003

23 Martinez SD, "Non-erosive reflux disease (NERD)-acid reflux and symptom patterns" 17 : 537-545, 2003

24 Ruigómez A, "Natural history of gastro-oesophageal reflux disease diagnosed in general practice" 20 : 751-760, 2004

25 Nakamura T, "Minimal change oesophagitis: a disease with characteristic differences to erosive oesophagitis" 21 (21): 19-26, 2005

26 Wileman SM, "Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults" 3 : CD003243-, 2010

27 Ang D, "Mechanisms of heartburn" 5 : 383-392, 2008

28 Takubo K, "Is there a set of histologic changes that are invariably reflux associated?" 129 : 159-163, 2005

29 Lv J, "Investigation of relationships among gastroesophageal reflux disease subtypes using narrow band imaging magnifying endoscopy" 19 : 8391-8397, 2013

30 Lee YC, "Intraobserver and interobserver consistency for grading esophagitis with narrow-band imaging" 66 : 230-236, 2007

31 Ronkainen J, "High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: a Kalixanda study report" 40 : 275-285, 2005

32 Lind T, "Heartburn without oesophagitis:efficacy of omeprazole therapy and features determining therapeutic response" 32 : 974-979, 1997

33 Katz PO, "Guidelines for the diagnosis and management of gastroesophageal reflux disease" 108 : 308-328-quiz 329, 2013

34 Vakil N, "Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus" 101 : 1900-1943, 2006

35 Quigley EM, "Getting categorical on GERD" 102 : 1130-, 2007

36 Fass R, "Gastroesophageal reflux disease-should we adopt a new conceptual framework?" 97 : 1901-1909, 2002

37 Carlsson R, "Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. International GORD study group" 10 : 119-124, 1998

38 Kaminski DL, "Evaluation of the use of the median arcuate ligament in fundoplication for reflux esophagitis" 134 : 724-729, 1977

39 Zerbib F, "Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy" 101 : 1956-1963, 2006

40 van Malenstein H, "Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease" 103 : 1021-1028, 2008

41 Dent J, "Epidemiology of gastro-oesophageal reflux disease: a systematic review" 54 : 710-717, 2005

42 Fass R, "Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease" 98 (98): S2-S7, 2003

43 Lundell LR, "Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification" 45 : 172-180, 1999

44 Dean BB, "Effectiveness of proton pump inhibitors in nonerosive reflux disease" 2 : 656-664, 2004

45 Emerenziani S, "Effect of oesophagitis on proximal extent of gastro-oesophageal reflux" 19 : 459-464, 2007

46 Fujiwara Y, "Differences in clinical characteristics between patients with endoscopy-negative reflux disease and erosive esophagitis in Japan" 100 : 754-758, 2005

47 Bredenoord AJ, "Determinants of perception of heartburn and regurgitation" 55 : 313-318, 2006

48 Zerbib F, "Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors" 57 : 156-160, 2008

49 Chen CL, "Current advances in the diagnosis and treatment of nonerosive reflux disease" 2013 : 653989-, 2013

50 Farré R, "Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces" 56 : 1191-1197, 2007

51 Dickman R, "Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD)groups" 101 : 2463-2469, 2006

52 Okamoto K, "Clinical symptoms in endoscopic reflux esophagitis: evaluation in 8031 adult subjects" 48 : 2237-2241, 2003

53 Cameron AJ, "Barrett's esophagus: prevalence and size of hiatal hernia" 94 : 2054-2059, 1999

54 Kotzan J, "Assessing NSAID prescription use as a predisposing factor for gastroesophageal reflux disease in a medicaid population" 18 : 1367-1372, 2001

55 Dent J, "An evidence-based appraisal of reflux disease management-the Genval workshop report" 44 : S1-S16, 1998

56 Bredenoord AJ, "Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy" 101 : 453-459, 2006

57 Sharma P, "A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease" 133 : 454-464, 2007