콩 섭취가 폐경 후 여성의 골밀도 및 골대사 지표에 미치는 영향 = Effect of Soybean Intake on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women

다국어 초록 (Multilingual Abstract)

Effect of Soybean Intake on Bone Mineral Density
and Bone Turnover Markers in Postmenopausal Women

Son, Gye-Soon1)

1) The Aju of Primary Health Care Post


Objective: The purpose of this study was to evaluate the effects of soybean intake on bone mineral density and bone turnover markers in postmenopausal rural Korean women. Method: This study was carried out during nine months from Oct. 25 2004 to Aug. 31 2005. The subjects of this study were female patients over 50 living in rural areas diagnosed with osteoporosis. There were 18 women in the experimental group and 20 in the control group. In this study, the experimental group received 100 mg of isoflavone (soybean) and calcium 1,500 mg for nine months while the control group received 1,500㎎ of calcium only. Results: After the soybean intake, the change of bone mineral density between the experimental group and control group was statistically significant. However, the bone turnover markers of osteocalcin and deoxypyridinoline between the experimental group and control group were not significantly different statistically. In the Pearson Correlation between bone mineral density and bone turnover markers, the osteocalcin and deoxypyridinoline of the experimental group had a positive correlation, and osteocalcin and DPD/osteocalcin ratio had anegative correlation. In the control group, osteocalcin and DPD/osteocalcin ratio had a negative correlation. Conclusions: This result showed that soybean intake changed bone mineral density in postmenopausal woman.

참고문헌 (Reference)

1 "Yearbook of Health and Welfare Statistics" 2004

2 "The purpose of this study was to evaluate the effects of soybean intake on bone mineral density and bone turnover markers in postmenopausal rural Korean women This study was carried out during nine months from Oct 25 2004 to Aug The subjects of this study were female patients over 50 living in rural areas diagnosed with osteoporosis There were 18 women in the experimental group and 20 in the control group the experimental group received 100 mg of isoflavone 500 mg for nine months while the control group received 1" 31-2005,

3 "The prevention and treatment of osteoporosis" 620-627, 1992

4 "The postmenopausal intervention cohort study group" 338 : 485-492, 1998

5 "The effect of education for prevention of osteoporosis patients with bone fracture" 31 (31): 194-205, 2001

6 "The distribution and transition of postmenopausal population in Korea" 4 (4): 61-71, 1998

7 "The Aju of Primary Health Care Post"

8 "Soy protein and isoflavones their effects on blood lipids and bone density in postmenopausal women" 68 : 1375s-1379s, 1998

9 "Soy for breast cancer survivors : A critical review of the literature." 131 : 3095S-3108S, 2001

10 "Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine" 208 : 18-26, 1995

11 "Quantitative ultrasound for osteoporosis screening in postmenopausal women" Chonnam National University 2001

12 "Metabolic bone disease-Harrison's principles of internal medicine" McGrow-Hill Co 1998

13 "Menopausal women and activity" 1 (1): 1-7, 2001

14 "Isoflavone contents, antioxidative and fibrinolytic activities of some commercial cooking-with-Rice soybeans." 34 (34): 498-504, 2002

15 "Isoflavone content in soybean and its processed products" 34 (34): 365-369, 2002

16 "Hormone replacement therapy in postmenopausal women : Urinary N-telopeptide of type Ⅰ collagen monitors therapeutic effect and predicts response of bone mineral density." 102 : 29-377, 1997

17 "Fast facts on osteoporosis" 1998

18 "Evaluation and treatment of postmenopausal osteoporosis" 27 : 245-261, 1998

19 "Effects of soybean foods intake on menopausal symptoms and bone metabolism in middle-aged women" Ewha Womans University 2003

20 "Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links" j clin endocri (j clin endocri): 367-73, 1991

21 "Effect of alcohol drinking on bone mineral density and serum estradiol level in postmenopausal women" 7 (7): 143-153, 2001

22 "Effect of Soybean Intake on Bone Mineral Density and Bone Turnover Markers in Postmenopausal WomenSon"

23 "Dietary phyto-oestrogens and the menopause in Japan" 210-223, 1992

24 "Clinical utilization of biochemical bone-mark after treatment of bone-absorption restraint among osteosis of Postmenopausal Women" Seoul National University 2002

25 "Changes of markers of bone turnover and spinal BMD after 1 year treatment according to treatment strategies & predictability of changes of BMD by changes of bone markers in Korean postmenopausal women with osteoporosis." 22 (22): 1234-1246, 2001

26 "An analysis of the relationship of menopausal symptoms of midlife women between urban area and rural area" 4 (4): 332-347, 1998

27 "Aerobic exercise and bone density at the hip in postmenopausal women: A meta-analysis." 27 (27): 798-807, 1998

28 "A study on dietary isoflavone intake, serum and urinary isoflavone concentrations, and BMD(bone mineral density) in korean postmenopausal women." Sookmyung Women's University 2000

29 "A study of health promotion behavior in farming people" 25 (25): 327-342, 2000

30 "A comparison of oral micronized effects on tail skin temperatures of ovariectomized rats." 8 : 171-174, 2001